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Semantic Scholar Open Access 2016 570 sitasi

The spotted gar genome illuminates vertebrate evolution and facilitates human-to-teleost comparisons

I. Braasch Andrew R. Gehrke J. Smith K. Kawasaki T. Manousaki +56 lainnya
Lihat Sumber DOI

Abstrak

To connect human biology to fish biomedical models, we sequenced the genome of spotted gar (Lepisosteus oculatus), whose lineage diverged from teleosts before teleost genome duplication (TGD). The slowly evolving gar genome has conserved in content and size many entire chromosomes from bony vertebrate ancestors. Gar bridges teleosts to tetrapods by illuminating the evolution of immunity, mineralization and development (mediated, for example, by Hox, ParaHox and microRNA genes). Numerous conserved noncoding elements (CNEs; often cis regulatory) undetectable in direct human-teleost comparisons become apparent using gar: functional studies uncovered conserved roles for such cryptic CNEs, facilitating annotation of sequences identified in human genome-wide association studies. Transcriptomic analyses showed that the sums of expression domains and expression levels for duplicated teleost genes often approximate the patterns and levels of expression for gar genes, consistent with subfunctionalization. The gar genome provides a resource for understanding evolution after genome duplication, the origin of vertebrate genomes and the function of human regulatory sequences.

Topik & Kata Kunci

Biology Medicine

Penulis (61)

I

I. Braasch

A

Andrew R. Gehrke

J

J. Smith

K

K. Kawasaki

T

T. Manousaki

J

Jérémy Pasquier

A

A. Amores

T

T. Desvignes

P

P. Batzel

J

J. Catchen

A

A. Berlin

M

Michael Campbell

D

D. Barrell

K

K. Martin

J

J. Mulley

V

V. Ravi

A

Alison P. Lee

T

Tetsuya Nakamura

D

D. Chalopin

S

Shaohua Fan

D

Dustin J. Wcisel

C

C. Cañestro

J

Jason Sydes

F

F. Beaudry

Y

Yi Sun

J

Jana Hertel

M

Michael J. Beam

M

M. Fasold

M

M. Ishiyama

J

Jeremy Johnson

S

Steffi Kehr

M

M. Lara

J

John H Letaw

G

G. Litman

R

R. Litman

M

M. Mikami

T

T. Ota

N

N. Saha

L

Louise Williams

P

P. Stadler

H

Han Wang

J

J. Taylor

Q

Q. Fontenot

A

A. Ferrara

S

S. Searle

B

Bronwen L. Aken

M

M. Yandell

I

Igor Schneider

J

J. Yoder

J

J. Volff

A

A. Meyer

C

C. Amemiya

B

B. Venkatesh

P

P. Holland

Y

Y. Guiguen

J

J. Bobe

N

N. Shubin

F

F. Di Palma

J

Jessica Alföldi

K

K. Lindblad-Toh

J

J. Postlethwait

Format Sitasi

APA MLA BibTeX
Braasch, I., Gehrke, A.R., Smith, J., Kawasaki, K., Manousaki, T., Pasquier, J. et al. (2016). The spotted gar genome illuminates vertebrate evolution and facilitates human-to-teleost comparisons. https://doi.org/10.1038/ng.3526

Akses Cepat

Lihat di Sumber doi.org/10.1038/ng.3526
Informasi Jurnal
Tahun Terbit
2016
Bahasa
en
Total Sitasi
570×
Sumber Database
Semantic Scholar
DOI
10.1038/ng.3526
Akses
Open Access ✓