Semantic Scholar Open Access 2005 1194 sitasi

A comprehensive pathway map of epidermal growth factor receptor signaling

Kanae Oda Yukiko Matsuoka Akira Funahashi H. Kitano

Lihat Sumber DOI

Abstrak

The epidermal growth factor receptor (EGFR) signaling pathway is one of the most important pathways that regulate growth, survival, proliferation, and differentiation in mammalian cells. Reflecting this importance, it is one of the best‐investigated signaling systems, both experimentally and computationally, and several computational models have been developed for dynamic analysis. A map of molecular interactions of the EGFR signaling system is a valuable resource for research in this area. In this paper, we present a comprehensive pathway map of EGFR signaling and other related pathways. The map reveals that the overall architecture of the pathway is a bow‐tie (or hourglass) structure with several feedback loops. The map is created using CellDesigner software that enables us to graphically represent interactions using a well‐defined and consistent graphical notation, and to store it in Systems Biology Markup Language (SBML).

Topik & Kata Kunci

Medicine Biology

Penulis (4)

Kanae Oda

Yukiko Matsuoka

Akira Funahashi

H. Kitano

Format Sitasi

APA MLA BibTeX

Oda, K., Matsuoka, Y., Funahashi, A., Kitano, H. (2005). A comprehensive pathway map of epidermal growth factor receptor signaling. https://doi.org/10.1038/msb4100014

Akses Cepat

Lihat di Sumber doi.org/10.1038/msb4100014

Informasi Jurnal

Tahun Terbit: 2005
Bahasa: en
Total Sitasi: 1194×
Sumber Database: Semantic Scholar
DOI: 10.1038/msb4100014
Akses: Open Access ✓