Semantic Scholar Open Access 2018 190 sitasi

Locked nucleic acid: modality, diversity, and drug discovery.

P. Hagedorn R. Persson E. Funder Nanna Albæk Sanna L. Diemer +8 lainnya

Lihat Sumber DOI

Abstrak

Over the past 20 years, the field of RNA-targeted therapeutics has advanced based on discoveries of modified oligonucleotide chemistries, and an ever-increasing understanding of how to apply cellular assays to identify oligonucleotides with improved pharmacological properties in vivo. Locked nucleic acid (LNA), which exhibits high binding affinity and potency, is widely used for this purpose. Our understanding of RNA biology has also expanded tremendously, resulting in new approaches to engage RNA as a therapeutic target. Recent observations indicate that each oligonucleotide is a unique entity, and small structural differences between oligonucleotides can often lead to substantial differences in their pharmacological properties. Here, we outline new principles for drug discovery exploiting oligonucleotide diversity to identify rare molecules with unique pharmacological properties.

Topik & Kata Kunci

Biology Medicine

Penulis (13)

P. Hagedorn

R. Persson

E. Funder

Nanna Albæk

Sanna L. Diemer

D. Hansen

M. R. Møller

Natalia Papargyri

Helle Christiansen

B. Hansen

H. Hansen

M. A. Jensen

T. Koch

Format Sitasi

APA MLA BibTeX

Hagedorn, P., Persson, R., Funder, E., Albæk, N., Diemer, S.L., Hansen, D. et al. (2018). Locked nucleic acid: modality, diversity, and drug discovery.. https://doi.org/10.1016/j.drudis.2017.09.018

Akses Cepat

Lihat di Sumber doi.org/10.1016/j.drudis.2017.09.018

Informasi Jurnal

Tahun Terbit: 2018
Bahasa: en
Total Sitasi: 190×
Sumber Database: Semantic Scholar
DOI: 10.1016/j.drudis.2017.09.018
Akses: Open Access ✓