Semantic Scholar Open Access 2012 10573 sitasi

Structure, Function and Diversity of the Healthy Human Microbiome

C. Huttenhower D. Gevers R. Knight Sahar Abubucker J. Badger +243 lainnya

Lihat Sumber DOI

Abstrak

Studies of the human microbiome have revealed that even healthy individuals differ remarkably in the microbes that occupy habitats such as the gut, skin and vagina. Much of this diversity remains unexplained, although diet, environment, host genetics and early microbial exposure have all been implicated. Accordingly, to characterize the ecology of human-associated microbial communities, the Human Microbiome Project has analysed the largest cohort and set of distinct, clinically relevant body habitats so far. We found the diversity and abundance of each habitat’s signature microbes to vary widely even among healthy subjects, with strong niche specialization both within and among individuals. The project encountered an estimated 81–99% of the genera, enzyme families and community configurations occupied by the healthy Western microbiome. Metagenomic carriage of metabolic pathways was stable among individuals despite variation in community structure, and ethnic/racial background proved to be one of the strongest associations of both pathways and microbes with clinical metadata. These results thus delineate the range of structural and functional configurations normal in the microbial communities of a healthy population, enabling future characterization of the epidemiology, ecology and translational applications of the human microbiome.

Topik & Kata Kunci

Medicine Biology

Penulis (248)

C. Huttenhower

D. Gevers

R. Knight

Sahar Abubucker

J. Badger

A. Chinwalla

H. Creasy

A. Earl

Michael G. Fitzgerald

R. Fulton

M. Giglio

Kymberlie Hallsworth-Pepin

E. Lobos

R. Madupu

V. Magrini

John Martin

M. Mitreva

D. Muzny

E. Sodergren

J. Versalovic

A. Wollam

K. Worley

J. Wortman

Sarah K. Young

Q. Zeng

K. Aagaard

Olukemi O. Abolude

E. Allen-Vercoe

E. Alm

Lucia Alvarado

G. Andersen

S. Anderson

Elizabeth L. Appelbaum

H. Arachchi

G. Armitage

Cesar Arze

T. Ayvaz

Carl C. Baker

L. Begg

Tsegahiwot Belachew

Veena Bhonagiri

Monika Bihan

M. Blaser

Toby Bloom

Vivien R. Bonazzi

J. Brooks

G. Buck

C. Buhay

D. Busam

Joseph L. Campbell

S. Canon

B. Cantarel

P. Chain

I. Chen

Lei Chen

Shaila Chhibba

Ken Chu

Dawn M. Ciulla

J. Clemente

S. Clifton

S. Conlan

J. Crabtree

M. Cutting

Noam J. Davidovics

Catherine C. Davis

T. DeSantis

C. Deal

Kimberley D. Delehaunty

F. Dewhirst

E. Deych

Yan Ding

D. Dooling

Shannon P. Dugan

W. Dunne

A. S. Durkin

Robert C. Edgar

R. Erlich

Candace N. Farmer

R. Farrell

Karoline Faust

M. Feldgarden

V. Felix

Sheila A Fisher

A. Fodor

L. Forney

Les Foster

V. D. Francesco

Jonathan Friedman

Dennis C. Friedrich

C. Fronick

L. Fulton

Hongyu Gao

Nathalia Garcia

G. Giannoukos

C. Giblin

Maria Y. Giovanni

J. Goldberg

Johannes Goll

Antonio Gonzalez

Allison D. Griggs

Sharvari Gujja

S. Haake

B. Haas

Holli A. Hamilton

Emily L. Harris

Theresa A. Hepburn

Brandi N. Herter

D. Hoffmann

M. Holder

Clinton Howarth

Katherine H. Huang

Susan M. Huse

J. Izard

J. Jansson

Huaiyang Jiang

Catherine Jordan

V. Joshi

J. Katancik

W. Keitel

S. Kelley

C. Kells

N. King

D. Knights

H. Kong

O. Koren

S. Koren

Karthik Kota

C. Kovar

N. Kyrpides

P. Rosa

Sandy Lee

K. P. Lemon

N. Lennon

Cecil M. Lewis

L. Lewis

R. Ley

Kelvin Li

K. Liolios

Bo Liu

Yue Liu

C. Lo

C. Lozupone

R. Lunsford

T. Madden

A. Mahurkar

P. Mannon

E. Mardis

V. Markowitz

K. Mavromatis

J. McCorrison

Daniel McDonald

J. Mcewen

A. McGuire

P. Mcinnes

Teena Mehta

K. Mihindukulasuriya

J. Miller

P. Minx

I. Newsham

C. Nusbaum

M. O'Laughlin

Joshua Orvis

I. Pagani

Krishna Palaniappan

Shital M. Patel

Matthew D. Pearson

Jane L. Peterson

M. Podar

C. Pohl

K. Pollard

Mihai Pop

M. Priest

L. Proctor

X. Qin

J. Raes

J. Ravel

J. Reid

Mina Rho

R. Rhodes

Kevin P. Riehle

M. Rivera

B. Rodriguez-Mueller

Y. Rogers

M. C. Ross

C. Russ

Ravi K. Sanka

P. Sankar

J. Sathirapongsasuti

J. Schloss

P. Schloss

T. Schmidt

M. Scholz

L. Schriml

Alyxandria M. Schubert

N. Segata

J. Segre

W. Shannon

R. Sharp

T. Sharpton

N. Shenoy

N. Sheth

Gina A. Simone

Indresh Singh

C. Smillie

J. Sobel

Daniel D. Sommer

P. Spicer

G. Sutton

S. Sykes

D. Tabbaa

M. Thiagarajan

Chad Tomlinson

M. Torralba

Todd J. Treangen

R. Truty

T. Vishnivetskaya

Jason R. Walker

Lu Wang

Zhengyuan O. Wang

D. Ward

W. Warren

M. Watson

Christopher Wellington

K. Wetterstrand

J. White

Katarzyna Wilczek-Boney

Yuanqing Wu

K. Wylie

T. Wylie

C. Yandava

Liang Ye

Yuzhen Ye

Shibu Yooseph

Bonnie P. Youmans

Lan Zhang

Yanjiao Zhou

Yiming Zhu

L. Zoloth

Jeremy D. Zucker

B. Birren

R. Gibbs

S. Highlander

B. Methé

K. Nelson

J. Petrosino

G. Weinstock

R. Wilson

O. White

Format Sitasi

APA MLA BibTeX

Huttenhower, C., Gevers, D., Knight, R., Abubucker, S., Badger, J., Chinwalla, A. et al. (2012). Structure, Function and Diversity of the Healthy Human Microbiome. https://doi.org/10.1038/nature11234

@article{huttenhower2012, author = {C. Huttenhower and D. Gevers and R. Knight and Sahar Abubucker and J. Badger and A. Chinwalla and H. Creasy and A. Earl and Michael G. Fitzgerald and R. Fulton and M. Giglio and Kymberlie Hallsworth-Pepin and E. Lobos and R. Madupu and V. Magrini and John Martin and M. Mitreva and D. Muzny and E. Sodergren and J. Versalovic and A. Wollam and K. Worley and J. Wortman and Sarah K. Young and Q. Zeng and K. Aagaard and Olukemi O. Abolude and E. Allen-Vercoe and E. Alm and Lucia Alvarado and G. Andersen and S. Anderson and Elizabeth L. Appelbaum and H. Arachchi and G. Armitage and Cesar Arze and T. Ayvaz and Carl C. Baker and L. Begg and Tsegahiwot Belachew and Veena Bhonagiri and Monika Bihan and M. Blaser and Toby Bloom and Vivien R. Bonazzi and J. Brooks and G. Buck and C. Buhay and D. Busam and Joseph L. Campbell and S. Canon and B. Cantarel and P. Chain and I. Chen and Lei Chen and Shaila Chhibba and Ken Chu and Dawn M. Ciulla and J. Clemente and S. Clifton and S. Conlan and J. Crabtree and M. Cutting and Noam J. Davidovics and Catherine C. Davis and T. DeSantis and C. Deal and Kimberley D. Delehaunty and F. Dewhirst and E. Deych and Yan Ding and D. Dooling and Shannon P. Dugan and W. Dunne and A. S. Durkin and Robert C. Edgar and R. Erlich and Candace N. Farmer and R. Farrell and Karoline Faust and M. Feldgarden and V. Felix and Sheila A Fisher and A. Fodor and L. Forney and Les Foster and V. D. Francesco and Jonathan Friedman and Dennis C. Friedrich and C. Fronick and L. Fulton and Hongyu Gao and Nathalia Garcia and G. Giannoukos and C. Giblin and Maria Y. Giovanni and J. Goldberg and Johannes Goll and Antonio Gonzalez and Allison D. Griggs and Sharvari Gujja and S. Haake and B. Haas and Holli A. Hamilton and Emily L. Harris and Theresa A. Hepburn and Brandi N. Herter and D. Hoffmann and M. Holder and Clinton Howarth and Katherine H. Huang and Susan M. Huse and J. Izard and J. Jansson and Huaiyang Jiang and Catherine Jordan and V. Joshi and J. Katancik and W. Keitel and S. Kelley and C. Kells and N. King and D. Knights and H. Kong and O. Koren and S. Koren and Karthik Kota and C. Kovar and N. Kyrpides and P. Rosa and Sandy Lee and K. P. Lemon and N. Lennon and Cecil M. Lewis and L. Lewis and R. Ley and Kelvin Li and K. Liolios and Bo Liu and Yue Liu and C. Lo and C. Lozupone and R. Lunsford and T. Madden and A. Mahurkar and P. Mannon and E. Mardis and V. Markowitz and K. Mavromatis and J. McCorrison and Daniel McDonald and J. Mcewen and A. McGuire and P. Mcinnes and Teena Mehta and K. Mihindukulasuriya and J. Miller and P. Minx and I. Newsham and C. Nusbaum and M. O'Laughlin and Joshua Orvis and I. Pagani and Krishna Palaniappan and Shital M. Patel and Matthew D. Pearson and Jane L. Peterson and M. Podar and C. Pohl and K. Pollard and Mihai Pop and M. Priest and L. Proctor and X. Qin and J. Raes and J. Ravel and J. Reid and Mina Rho and R. Rhodes and Kevin P. Riehle and M. Rivera and B. Rodriguez-Mueller and Y. Rogers and M. C. Ross and C. Russ and Ravi K. Sanka and P. Sankar and J. Sathirapongsasuti and J. Schloss and P. Schloss and T. Schmidt and M. Scholz and L. Schriml and Alyxandria M. Schubert and N. Segata and J. Segre and W. Shannon and R. Sharp and T. Sharpton and N. Shenoy and N. Sheth and Gina A. Simone and Indresh Singh and C. Smillie and J. Sobel and Daniel D. Sommer and P. Spicer and G. Sutton and S. Sykes and D. Tabbaa and M. Thiagarajan and Chad Tomlinson and M. Torralba and Todd J. Treangen and R. Truty and T. Vishnivetskaya and Jason R. Walker and Lu Wang and Zhengyuan O. Wang and D. Ward and W. Warren and M. Watson and Christopher Wellington and K. Wetterstrand and J. White and Katarzyna Wilczek-Boney and Yuanqing Wu and K. Wylie and T. Wylie and C. Yandava and Liang Ye and Yuzhen Ye and Shibu Yooseph and Bonnie P. Youmans and Lan Zhang and Yanjiao Zhou and Yiming Zhu and L. Zoloth and Jeremy D. Zucker and B. Birren and R. Gibbs and S. Highlander and B. Methé and K. Nelson and J. Petrosino and G. Weinstock and R. Wilson and O. White}, title = {Structure, Function and Diversity of the Healthy Human Microbiome}, year = {2012}, journal = {Semantic Scholar}, doi = {10.1038/nature11234}, url = {https://www.semanticscholar.org/paper/1016e40b12899d3f409166ada638e1bf62edeb63}, }

Akses Cepat

Lihat di Sumber doi.org/10.1038/nature11234

Informasi Jurnal

Tahun Terbit: 2012
Bahasa: en
Total Sitasi: 10573×
Sumber Database: Semantic Scholar
DOI: 10.1038/nature11234
Akses: Open Access ✓