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Semantic Scholar Open Access 2021 3805 sitasi

Natural products in drug discovery: advances and opportunities

A. Atanasov S. Zotchev V. Dirsch Ilkay Erdogan Maciej Judith M. Davide Wolfram Rudolf Edw Orhan Banach Rollinger Barreca Weckwerth Bauer Bay I. Orhan +69 lainnya
Lihat Sumber DOI

Abstrak

Natural products and their structural analogues have historically made a major contribution to pharmacotherapy, especially for cancer and infectious diseases. Nevertheless, natural products also present challenges for drug discovery, such as technical barriers to screening, isolation, characterization and optimization, which contributed to a decline in their pursuit by the pharmaceutical industry from the 1990s onwards. In recent years, several technological and scientific developments — including improved analytical tools, genome mining and engineering strategies, and microbial culturing advances — are addressing such challenges and opening up new opportunities. Consequently, interest in natural products as drug leads is being revitalized, particularly for tackling antimicrobial resistance. Here, we summarize recent technological developments that are enabling natural product-based drug discovery, highlight selected applications and discuss key opportunities. Natural products have historically made a major contribution to pharmacotherapy, but also present challenges for drug discovery, such as technical barriers to screening, isolation, characterization and optimization. This Review discusses recent technological developments — including improved analytical tools, genome mining and engineering strategies, and microbial culturing advances — that are enabling a revitalization of natural product-based drug discovery.

Topik & Kata Kunci

Medicine

Penulis (74)

A

A. Atanasov

S

S. Zotchev

V

V. Dirsch

I

Ilkay Erdogan Maciej Judith M. Davide Wolfram Rudolf Edw Orhan Banach Rollinger Barreca Weckwerth Bauer Bay

I

I. Orhan

M

M. Banach

J

J. Rollinger

D

D. Barreca

W

W. Weckwerth

R

R. Bauer

E

E. Bayer

M

M. Majeed

A

A. Bishayee

V

V. Bochkov

G

G. Bonn

N

N. Braidy

F

F. Bucar

A

A. Cifuentes

G

G. D’Onofrio

M

Michael A. Bodkin

M

M. Diederich

A

A. Dinkova-Kostova

T

T. Efferth

K

Khalid El Bairi

N

N. Arkells

T

Tai-Ping Fan

B

B. Fiebich

M

M. Freissmuth

M

M. Georgiev

S

S. Gibbons

K

K. Godfrey

C

Christian W. Gruber

J

J. Heer

L

Lukas A. Huber

E

E. Ibáñez

A

A. Kijjoa

A

A. Kiss

A

Aiping Lu

F

F. A. Macias

M

Mark J. S. Miller

A

A. Mocan

R

Rolf Müller

F

F. Nicoletti

G

George Perry

V

V. Pittalà

L

L. Rastrelli

M

M. Ristow

G

G. Russo

A

A. S. Silva

D

D. Schuster

H

H. Sheridan

K

K. Skalicka‐Woźniak

L

L. Skaltsounis

E

E. Sobarzo-Sánchez

D

D. Bredt

H

H. Stuppner

A

A. Sureda

N

N. Tzvetkov

R

R. A. Vacca

B

Bharat B. Aggarwal

M

M. Battino

F

Francesca Giampieri

M

M. Wink

J

J. Wolfender

J

Jianbo Xiao

A

A. Yeung

G

G. Lizard

M

M. Popp

M

Michael Heinrich

I

I. Berindan‐Neagoe

M

M. Stadler

M

M. Daglia

R

R. Verpoorte

C

C. Supuran

Format Sitasi

APA MLA BibTeX
Atanasov, A., Zotchev, S., Dirsch, V., Bay, I.E.M.J.M.D.W.R.E.O.B.R.B.W.B., Orhan, I., Banach, M. et al. (2021). Natural products in drug discovery: advances and opportunities. https://doi.org/10.1038/s41573-020-00114-z

Akses Cepat

Lihat di Sumber doi.org/10.1038/s41573-020-00114-z
Informasi Jurnal
Tahun Terbit
2021
Bahasa
en
Total Sitasi
3805×
Sumber Database
Semantic Scholar
DOI
10.1038/s41573-020-00114-z
Akses
Open Access ✓