Semantic Scholar Open Access 2022 1117 sitasi

Pharmaceutical pollution of the world’s rivers

J. Wilkinson A. Boxall D. Kolpin Kenneth M Y Leung R. W. Lai +122 lainnya

Lihat Sumber DOI

Abstrak

Significance Despite growing evidence of the deleterious effects on ecological and human health, little is known regarding the global occurrence of pharmaceuticals in rivers. Studies assessing their occurrence are available for 75 of 196 countries, with most research conducted in North America and Western Europe. This leaves large geographical regions relatively unstudied. Here, we present the findings of a global reconnaissance of pharmaceutical pollution in rivers. The study monitored 1,052 sampling sites along 258 rivers in 104 countries of all continents, thus representing the pharmaceutical fingerprint of 471.4 million people. We show that the presence of these contaminants in surface water poses a threat to environmental and/or human health in more than a quarter of the studied locations globally. Environmental exposure to active pharmaceutical ingredients (APIs) can have negative effects on the health of ecosystems and humans. While numerous studies have monitored APIs in rivers, these employ different analytical methods, measure different APIs, and have ignored many of the countries of the world. This makes it difficult to quantify the scale of the problem from a global perspective. Furthermore, comparison of the existing data, generated for different studies/regions/continents, is challenging due to the vast differences between the analytical methodologies employed. Here, we present a global-scale study of API pollution in 258 of the world’s rivers, representing the environmental influence of 471.4 million people across 137 geographic regions. Samples were obtained from 1,052 locations in 104 countries (representing all continents and 36 countries not previously studied for API contamination) and analyzed for 61 APIs. Highest cumulative API concentrations were observed in sub-Saharan Africa, south Asia, and South America. The most contaminated sites were in low- to middle-income countries and were associated with areas with poor wastewater and waste management infrastructure and pharmaceutical manufacturing. The most frequently detected APIs were carbamazepine, metformin, and caffeine (a compound also arising from lifestyle use), which were detected at over half of the sites monitored. Concentrations of at least one API at 25.7% of the sampling sites were greater than concentrations considered safe for aquatic organisms, or which are of concern in terms of selection for antimicrobial resistance. Therefore, pharmaceutical pollution poses a global threat to environmental and human health, as well as to delivery of the United Nations Sustainable Development Goals.

Topik & Kata Kunci

Medicine

Penulis (127)

J. Wilkinson

A. Boxall

D. Kolpin

Kenneth M Y Leung

R. W. Lai

C. Galbán-Malagón

A. Adell

J. Mondon

M. Metian

R. Marchant

Alejandra Bouzas-Monroy

A. Cuni‐Sanchez

A. Coors

P. Carriquiriborde

M. Rojo

C. Gordon

M. Cara

Monique Moermond

T. Luarte

V. Petrosyan

Yekaterina Perikhanyan

Clare Mahon

Christopher J. McGurk

T. Hofmann

Tapos Kormoker

V. Iñiguez

Jessica Guzman-Otazo

J. L. Tavares

Francisco Gildasio De Figueiredo

M. Razzolini

V. Dougnon

G. Gbaguidi

O. Traoré

J. Blais

L. Kimpe

Michelle R Wong

Don Wong

R. Ntchantcho

J. Pizarro

G. Ying

Chang-Er Chen

M. Páez

Jina M. Martínez-Lara

J. Otamonga

J. Poté

S. Ifo

P. Wilson

Silvia Echeverría-Sáenz

N. Udiković-Kolić

Milena Milakovic

D. Fatta-Kassinos

L. Ioannou-Ttofa

Vladimíra Belušová

J. Vymazal

María Cárdenas-Bustamante

Bayable A Kassa

J. Garric

A. Chaumot

P. Gibba

Ilia Kunchulia

Sven Seidensticker

G. Lyberatos

H. Halldórsson

Molly Melling

T. Shashidhar

M. Lamba

A. Nastiti

A. Supriatin

N. Pourang

Alireza Abedini

O. Abdullah

Salem S. Gharbia

F. Pilla

B. Chefetz

T. Topaz

K. M. Yao

B. Aubakirova

R. Beisenova

L. Olaka

Jemimah K Mulu

Peter Chatanga

V. Ntuli

Nathaniel T Blama

S. Sherif

A. Aris

L. Looi

M. Niang

Seydou T. Traoré

R. Oldenkamp

Olatayo Ogunbanwo

Muhammad Ashfaq

Muhammad Iqbal

Z. Abdeen

A. O’Dea

J. Morales‐Saldaña

M. Custodio

H. de la Cruz

I. Navarrete

Fabio Carvalho

A. B. Gogra

B. Koroma

V. Cerkvenik-Flajs

M. Gombač

M. Thwala

Kyungho Choi

Habyeong Kang

J. Ladu

A. Rico

P. Amerasinghe

Anna Sobek

G. Horlitz

Armin K. Zenker

A. King

Jheng-Jie Jiang

Rebecca W. Kariuki

M. Tumbo

U. Tezel

T. Onay

J. Lejju

Y. Vystavna

Y. Vergeles

H. Heinzen

A. Pérez-Parada

D. Sims

Maritza Figy

D. Good

C. Teta

Format Sitasi

APA MLA BibTeX

Wilkinson, J., Boxall, A., Kolpin, D., Leung, K.M.Y., Lai, R.W., Galbán-Malagón, C. et al. (2022). Pharmaceutical pollution of the world’s rivers. https://doi.org/10.1073/pnas.2113947119

@article{wilkinson2022, author = {J. Wilkinson and A. Boxall and D. Kolpin and Kenneth M Y Leung and R. W. Lai and C. Galbán-Malagón and A. Adell and J. Mondon and M. Metian and R. Marchant and Alejandra Bouzas-Monroy and A. Cuni‐Sanchez and A. Coors and P. Carriquiriborde and M. Rojo and C. Gordon and M. Cara and Monique Moermond and T. Luarte and V. Petrosyan and Yekaterina Perikhanyan and Clare Mahon and Christopher J. McGurk and T. Hofmann and Tapos Kormoker and V. Iñiguez and Jessica Guzman-Otazo and J. L. Tavares and Francisco Gildasio De Figueiredo and M. Razzolini and V. Dougnon and G. Gbaguidi and O. Traoré and J. Blais and L. Kimpe and Michelle R Wong and Don Wong and R. Ntchantcho and J. Pizarro and G. Ying and Chang-Er Chen and M. Páez and Jina M. Martínez-Lara and J. Otamonga and J. Poté and S. Ifo and P. Wilson and Silvia Echeverría-Sáenz and N. Udiković-Kolić and Milena Milakovic and D. Fatta-Kassinos and L. Ioannou-Ttofa and Vladimíra Belušová and J. Vymazal and María Cárdenas-Bustamante and Bayable A Kassa and J. Garric and A. Chaumot and P. Gibba and Ilia Kunchulia and Sven Seidensticker and G. Lyberatos and H. Halldórsson and Molly Melling and T. Shashidhar and M. Lamba and A. Nastiti and A. Supriatin and N. Pourang and Alireza Abedini and O. Abdullah and Salem S. Gharbia and F. Pilla and B. Chefetz and T. Topaz and K. M. Yao and B. Aubakirova and R. Beisenova and L. Olaka and Jemimah K Mulu and Peter Chatanga and V. Ntuli and Nathaniel T Blama and S. Sherif and A. Aris and L. Looi and M. Niang and Seydou T. Traoré and R. Oldenkamp and Olatayo Ogunbanwo and Muhammad Ashfaq and Muhammad Iqbal and Z. Abdeen and A. O’Dea and J. Morales‐Saldaña and M. Custodio and H. de la Cruz and I. Navarrete and Fabio Carvalho and A. B. Gogra and B. Koroma and V. Cerkvenik-Flajs and M. Gombač and M. Thwala and Kyungho Choi and Habyeong Kang and J. Ladu and A. Rico and P. Amerasinghe and Anna Sobek and G. Horlitz and Armin K. Zenker and A. King and Jheng-Jie Jiang and Rebecca W. Kariuki and M. Tumbo and U. Tezel and T. Onay and J. Lejju and Y. Vystavna and Y. Vergeles and H. Heinzen and A. Pérez-Parada and D. Sims and Maritza Figy and D. Good and C. Teta}, title = {Pharmaceutical pollution of the world’s rivers}, year = {2022}, journal = {Semantic Scholar}, doi = {10.1073/pnas.2113947119}, url = {https://www.semanticscholar.org/paper/0bb466d43babd0af1fe6c385e8f8a3c68e768f9b}, }

Akses Cepat

Lihat di Sumber doi.org/10.1073/pnas.2113947119

Informasi Jurnal

Tahun Terbit: 2022
Bahasa: en
Total Sitasi: 1117×
Sumber Database: Semantic Scholar
DOI: 10.1073/pnas.2113947119
Akses: Open Access ✓