Semantic Scholar Open Access 2002 703 sitasi

CDART: protein homology by domain architecture.

Lewis Y. Geer M. Domrachev D. Lipman S. Bryant

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Abstrak

The Conserved Domain Architecture Retrieval Tool (CDART) performs similarity searches of the NCBI Entrez Protein Database based on domain architecture, defined as the sequential order of conserved domains in proteins. The algorithm finds protein similarities across significant evolutionary distances using sensitive protein domain profiles rather than by direct sequence similarity. Proteins similar to a query protein are grouped and scored by architecture. Relying on domain profiles allows CDART to be fast, and, because it relies on annotated functional domains, informative. Domain profiles are derived from several collections of domain definitions that include functional annotation. Searches can be further refined by taxonomy and by selecting domains of interest. CDART is available at http://www.ncbi.nlm.nih.gov/Structure/lexington/lexington.cgi.

Topik & Kata Kunci

Medicine Biology

Penulis (4)

Lewis Y. Geer

M. Domrachev

D. Lipman

S. Bryant

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Geer, L.Y., Domrachev, M., Lipman, D., Bryant, S. (2002). CDART: protein homology by domain architecture.. https://doi.org/10.1101/GR.278202

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Lihat di Sumber doi.org/10.1101/GR.278202

Informasi Jurnal

Tahun Terbit: 2002
Bahasa: en
Total Sitasi: 703×
Sumber Database: Semantic Scholar
DOI: 10.1101/GR.278202
Akses: Open Access ✓