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Semantic Scholar Open Access 1996 620 sitasi

Adaptive Evolution of Human Immunodeficiency Virus-Type 1 During the Natural Course of Infection

Steven Wolinsky B. Korber A. Neumann Michael R. Daniels K. Kunstman +6 lainnya
Lihat Sumber DOI

Abstrak

The rate of progression to disease varies considerably among individuals infected with human immunodeficiency virus-type 1 (HIV-1). Analyses of semiannual blood samples obtained from six infected men showed that a rapid rate of CD4 T cell loss was associated with relative evolutionary stasis of the HIV-1 quasispecies virus population. More moderate rates of CD4 T cell loss correlated with genetic evolution within three of four subjects. Consistent with selection by the immune constraints of these subjects, amino acid changes were apparent within the appropriate epitopes of human leukocyte antigen class I-restricted cytotoxic T lymphocytes. Thus, the evolutionary dynamics exhibited by the HIV-1 quasispecies virus populations under natural selection are compatible with adaptive evolution.

Topik & Kata Kunci

Biology Medicine

Penulis (11)

S

Steven Wolinsky

B

B. Korber

A

A. Neumann

M

Michael R. Daniels

K

K. Kunstman

A

A. Whetsell

M

M. Furtado

Y

Yun-zhen Cao

D

D. Ho

J

J. Safrit

R

R. Koup

Format Sitasi

APA MLA BibTeX
Wolinsky, S., Korber, B., Neumann, A., Daniels, M.R., Kunstman, K., Whetsell, A. et al. (1996). Adaptive Evolution of Human Immunodeficiency Virus-Type 1 During the Natural Course of Infection. https://doi.org/10.1126/science.272.5261.537

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Informasi Jurnal
Tahun Terbit
1996
Bahasa
en
Total Sitasi
620×
Sumber Database
Semantic Scholar
DOI
10.1126/science.272.5261.537
Akses
Open Access ✓