THE MODERN STATE OF DEVELOPMENT AND APPLICATION OF PROBIOTICS, PREBIOTICS AND SYNBIOTICS

Mass uncontrolled use of antibiotics, environmentaldegradation, large amount of stress situations cause re-duction of adaptive abilities of human body, activate thesympathetic-adrenal system, which, in turn, causes theneurohumoral changes due to the imbalance of neuro-transmitters production, affecting specific and nonspe-cific resistance of the organism, as well as the microflora.According to WHO data, the number of people with dis-orders of immune system is constantly increasing. Thatleads to exacerbation of chronic diseases, including thosecaused by opportunistic pathogens. Thereby, it is veryimportant to develop appropriate methods for macroor-ganism’s optimum microflora restoring. The review sum-marizes the scientific data about composition, mecha-nisms of action and drug formulations of probiotics, pre-biotics and synbiotics. The probable complications aftertaking these drugs are described. The main problems as-sociated with the production and standardization of pro-biotic preparations and perspective directions aimed atthe normalization of microbial ecology are presented inthe article.