Current Perspectives on the Management of Infantile Atopic Dermatitis

Danielle R Davari, Elizabeth L Nieman, Diana B McShane, Dean S Morrell Department of Dermatology, University of North Carolina School of Medicine, Chapel Hill, NC, USACorrespondence: Dean S MorrellDepartment of Dermatology, University of North Carolina School of Medicine, 410 Market Street Suite 400, Chapel Hill, NC 27516, USATel +1 984 974 3900Fax +1 984 974 3692Email morrell@med.unc.eduAbstract: Atopic dermatitis (AD) is a common disease of childhood, and infantile AD may manifest from birth to 2 years. Guidelines for the management of infantile AD are lacking, and our aim is to provide a comprehensive review of best practices and possible interventions. We will focus on topical therapy, since the use of systemic immunomodulating agents in infantile AD is rarely advised. Topical agents include emollients, topical corticosteroids (TCS), topical calcineurin inhibitors (TCIs), and phosphodiesterase 4 (PDE-4) inhibitors. We will also provide a brief overview of promising emerging therapies currently under investigation in the pediatric population.Keywords: eczema, pediatric, infants, treatment