DOAJ Open Access 2024

Novel risk loci for COVID-19 hospitalization among admixed American populations

Silvia Diz-de Almeida Raquel Cruz Andre D Luchessi José M Lorenzo-Salazar Miguel López de Heredia +117 lainnya

Abstrak

The genetic basis of severe COVID-19 has been thoroughly studied, and many genetic risk factors shared between populations have been identified. However, reduced sample sizes from non-European groups have limited the discovery of population-specific common risk loci. In this second study nested in the SCOURGE consortium, we conducted a genome-wide association study (GWAS) for COVID-19 hospitalization in admixed Americans, comprising a total of 4702 hospitalized cases recruited by SCOURGE and seven other participating studies in the COVID-19 Host Genetic Initiative. We identified four genome-wide significant associations, two of which constitute novel loci and were first discovered in Latin American populations (BAZ2B and DDIAS). A trans-ethnic meta-analysis revealed another novel cross-population risk locus in CREBBP. Finally, we assessed the performance of a cross-ancestry polygenic risk score in the SCOURGE admixed American cohort. This study constitutes the largest GWAS for COVID-19 hospitalization in admixed Latin Americans conducted to date. This allowed to reveal novel risk loci and emphasize the need of considering the diversity of populations in genomic research.

Topik & Kata Kunci

Medicine Science Biology (General)

Penulis (122)

Silvia Diz-de Almeida

Raquel Cruz

Andre D Luchessi

José M Lorenzo-Salazar

Miguel López de Heredia

Inés Quintela

Rafaela González-Montelongo

Vivian Nogueira Silbiger

Marta Sevilla Porras

Jair Antonio Tenorio Castaño

Julian Nevado

Jose María Aguado

Carlos Aguilar

Sergio Aguilera-Albesa

Virginia Almadana

Berta Almoguera

Nuria Alvarez

Álvaro Andreu-Bernabeu

Eunate Arana-Arri

Celso Arango

María J Arranz

Maria-Jesus Artiga

Raúl C Baptista-Rosas

María Barreda- Sánchez

Moncef Belhassen-Garcia

Joao F Bezerra

Marcos AC Bezerra

Lucía Boix-Palop

María Brion

Ramón Brugada

Matilde Bustos

Enrique J Calderón

Cristina Carbonell

Luis Castano

Jose E Castelao

Rosa Conde-Vicente

M Lourdes Cordero-Lorenzana

Jose L Cortes-Sanchez

Marta Corton

M Teresa Darnaude

Alba De Martino-Rodríguez

Victor del Campo-Pérez

Aranzazu Diaz de Bustamante

Elena Domínguez-Garrido

Rocío Eirós

María Carmen Fariñas

María J Fernandez-Nestosa

Uxía Fernández-Robelo

Amanda Fernández-Rodríguez

Tania Fernández-Villa

Manuela Gago-Dominguez

Belén Gil-Fournier

Javier Gómez-Arrue

Beatriz González Álvarez

Fernan Gonzalez Bernaldo de Quirós

Anna González-Neira

Javier González-Peñas

Juan F Gutiérrez-Bautista

María José Herrero

Antonio Herrero-Gonzalez

María A Jimenez-Sousa

María Claudia Lattig

Anabel Liger Borja

Rosario Lopez-Rodriguez

Esther Mancebo

Caridad Martín-López

Vicente Martín

Oscar Martinez-Nieto

Iciar Martinez-Lopez

Michel F Martinez-Resendez

Angel Martinez-Perez

Juliana F Mazzeu

Eleuterio Merayo Macías

Pablo Minguez

Victor Moreno Cuerda

Silviene F Oliveira

Eva Ortega-Paino

Mara Parellada

Estela Paz-Artal

Ney PC Santos

Patricia Pérez-Matute

Patricia Perez

M Elena Pérez-Tomás

Teresa Perucho

Mellina Pinsach-Abuin

Guillermo Pita

Ericka N Pompa-Mera

Gloria L Porras-Hurtado

Aurora Pujol

Soraya Ramiro León

Salvador Resino

Marianne R Fernandes

Emilio Rodríguez-Ruiz

Fernando Rodriguez-Artalejo

José A Rodriguez-Garcia

Francisco Ruiz-Cabello

Javier Ruiz-Hornillos

Pablo Ryan

José Manuel Soria

Juan Carlos Souto

Eduardo Tamayo

Alvaro Tamayo-Velasco

Juan Carlos Taracido-Fernandez

Alejandro Teper

Lilian Torres-Tobar

Miguel Urioste

Juan Valencia-Ramos

Zuleima Yáñez

Ruth Zarate

Itziar de Rojas

Agustín Ruiz

Pascual Sánchez

Luis Miguel Real

SCOURGE Cohort Group

Encarna Guillen-Navarro

Carmen Ayuso

Esteban Parra

José A Riancho

Augusto Rojas-Martinez

Carlos Flores

Pablo Lapunzina

Ángel Carracedo

Format Sitasi

APA MLA BibTeX

Almeida, S.D., Cruz, R., Luchessi, A.D., Lorenzo-Salazar, J.M., Heredia, M.L.d., Quintela, I. et al. (2024). Novel risk loci for COVID-19 hospitalization among admixed American populations. https://doi.org/10.7554/eLife.93666

@article{almeida2024, author = {Silvia Diz-de Almeida and Raquel Cruz and Andre D Luchessi and José M Lorenzo-Salazar and Miguel López de Heredia and Inés Quintela and Rafaela González-Montelongo and Vivian Nogueira Silbiger and Marta Sevilla Porras and Jair Antonio Tenorio Castaño and Julian Nevado and Jose María Aguado and Carlos Aguilar and Sergio Aguilera-Albesa and Virginia Almadana and Berta Almoguera and Nuria Alvarez and Álvaro Andreu-Bernabeu and Eunate Arana-Arri and Celso Arango and María J Arranz and Maria-Jesus Artiga and Raúl C Baptista-Rosas and María Barreda- Sánchez and Moncef Belhassen-Garcia and Joao F Bezerra and Marcos AC Bezerra and Lucía Boix-Palop and María Brion and Ramón Brugada and Matilde Bustos and Enrique J Calderón and Cristina Carbonell and Luis Castano and Jose E Castelao and Rosa Conde-Vicente and M Lourdes Cordero-Lorenzana and Jose L Cortes-Sanchez and Marta Corton and M Teresa Darnaude and Alba De Martino-Rodríguez and Victor del Campo-Pérez and Aranzazu Diaz de Bustamante and Elena Domínguez-Garrido and Rocío Eirós and María Carmen Fariñas and María J Fernandez-Nestosa and Uxía Fernández-Robelo and Amanda Fernández-Rodríguez and Tania Fernández-Villa and Manuela Gago-Dominguez and Belén Gil-Fournier and Javier Gómez-Arrue and Beatriz González Álvarez and Fernan Gonzalez Bernaldo de Quirós and Anna González-Neira and Javier González-Peñas and Juan F Gutiérrez-Bautista and María José Herrero and Antonio Herrero-Gonzalez and María A Jimenez-Sousa and María Claudia Lattig and Anabel Liger Borja and Rosario Lopez-Rodriguez and Esther Mancebo and Caridad Martín-López and Vicente Martín and Oscar Martinez-Nieto and Iciar Martinez-Lopez and Michel F Martinez-Resendez and Angel Martinez-Perez and Juliana F Mazzeu and Eleuterio Merayo Macías and Pablo Minguez and Victor Moreno Cuerda and Silviene F Oliveira and Eva Ortega-Paino and Mara Parellada and Estela Paz-Artal and Ney PC Santos and Patricia Pérez-Matute and Patricia Perez and M Elena Pérez-Tomás and Teresa Perucho and Mellina Pinsach-Abuin and Guillermo Pita and Ericka N Pompa-Mera and Gloria L Porras-Hurtado and Aurora Pujol and Soraya Ramiro León and Salvador Resino and Marianne R Fernandes and Emilio Rodríguez-Ruiz and Fernando Rodriguez-Artalejo and José A Rodriguez-Garcia and Francisco Ruiz-Cabello and Javier Ruiz-Hornillos and Pablo Ryan and José Manuel Soria and Juan Carlos Souto and Eduardo Tamayo and Alvaro Tamayo-Velasco and Juan Carlos Taracido-Fernandez and Alejandro Teper and Lilian Torres-Tobar and Miguel Urioste and Juan Valencia-Ramos and Zuleima Yáñez and Ruth Zarate and Itziar de Rojas and Agustín Ruiz and Pascual Sánchez and Luis Miguel Real and SCOURGE Cohort Group and Encarna Guillen-Navarro and Carmen Ayuso and Esteban Parra and José A Riancho and Augusto Rojas-Martinez and Carlos Flores and Pablo Lapunzina and Ángel Carracedo}, title = {Novel risk loci for COVID-19 hospitalization among admixed American populations}, year = {2024}, journal = {DOAJ}, doi = {10.7554/eLife.93666}, url = {https://elifesciences.org/articles/93666}, }

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Informasi Jurnal

Tahun Terbit: 2024
Sumber Database: DOAJ
DOI: 10.7554/eLife.93666
Akses: Open Access ✓