DOAJ Open Access 2021

Copper-catalyzed N-arylation of bis(indolyl)methanes: the first approach for the synthesis of unsymmetrical N-aryl bis(indolyl)methanes by C–N cross-coupling reaction

Hassani Bagheri, Fatemeh Khabazzadeh, Hojatollah Fayazi, Maryam

Abstrak

This investigation describes an efficient method for the synthesis of unsymmetrical N-aryl bis(indolyl)methanes by C–N cross-coupling reaction of unsubstituted bis(indolyl)methanes with aryl iodides in the presence of several Cu salts and CuFe$_{2}$O$_{4}$ as homogeneous and heterogeneous catalysts, respectively. Among these Cu containing catalysts, CuFe$_{2}$O$_{4}$ under ligand-free conditions showed the best activity and selectivity for mono N-arylation of bis(indolyl)methanes. Notably, CuFe$_{2}$O$_{4}$ catalyst was recovered and reused several times.

Topik & Kata Kunci

Biochemistry Physical and theoretical chemistry Mathematics

Penulis (3)

Hassani Bagheri, Fatemeh

Khabazzadeh, Hojatollah

Fayazi, Maryam

Format Sitasi

APA MLA BibTeX

Fatemeh, H.B., Hojatollah, K., Maryam, F. (2021). Copper-catalyzed N-arylation of bis(indolyl)methanes: the first approach for the synthesis of unsymmetrical N-aryl bis(indolyl)methanes by C–N cross-coupling reaction. https://doi.org/10.5802/crchim.111

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Informasi Jurnal

Tahun Terbit: 2021
Sumber Database: DOAJ
DOI: 10.5802/crchim.111
Akses: Open Access ✓