DOAJ Open Access 2019

Male Oxidative Stress Infertility (MOSI): Proposed Terminology and Clinical Practice Guidelines for Management of Idiopathic Male Infertility

Ashok Agarwal Neel Parekh Manesh Kumar Panner Selvam Ralf Henkel Rupin Shah +86 lainnya

DOI

Abstrak

Despite advances in the field of male reproductive health, idiopathic male infertility, in which a man has altered semen characteristics without an identifiable cause and there is no female factor infertility, remains a challenging condition to diagnose and manage. Increasing evidence suggests that oxidative stress (OS) plays an independent role in the etiology of male infertility, with 30% to 80% of infertile men having elevated seminal reactive oxygen species levels. OS can negatively affect fertility via a number of pathways, including interference with capacitation and possible damage to sperm membrane and DNA, which may impair the sperm’s potential to fertilize an egg and develop into a healthy embryo. Adequate evaluation of male reproductive potential should therefore include an assessment of sperm OS. We propose the term Male Oxidative Stress Infertility, or MOSI, as a novel descriptor for infertile men with abnormal semen characteristics and OS, including many patients who were previously classified as having idiopathic male infertility. Oxidation-reduction potential (ORP) can be a useful clinical biomarker for the classification of MOSI, as it takes into account the levels of both oxidants and reductants (antioxidants). Current treatment protocols for OS, including the use of antioxidants, are not evidence-based and have the potential for complications and increased healthcare-related expenditures. Utilizing an easy, reproducible, and cost-effective test to measure ORP may provide a more targeted, reliable approach for administering antioxidant therapy while minimizing the risk of antioxidant overdose. With the increasing awareness and understanding of MOSI as a distinct male infertility diagnosis, future research endeavors can facilitate the development of evidence-based treatments that target its underlying cause.

Topik & Kata Kunci

Medicine Diseases of the genitourinary system. Urology

Penulis (91)

Ashok Agarwal

Neel Parekh

Manesh Kumar Panner Selvam

Ralf Henkel

Rupin Shah

Sheryl T. Homa

Ranjith Ramasamy

Edmund Ko

Kelton Tremellen

Sandro Esteves

Ahmad Majzoub

Juan G. Alvarez

David K. Gardner

Channa N. Jayasena

Jonathan W. Ramsay

Chak-Lam Cho

Ramadan Saleh

Denny Sakkas

James M. Hotaling

Scott D. Lundy

Sarah Vij

Joel Marmar

Jaime Gosalvez

Edmund Sabanegh

Hyun Jun Park

Armand Zini

Parviz Kavoussi

Sava Micic

Ryan Smith

Gian Maria Busetto

Mustafa Emre Bakırcıoğlu

Gerhard Haidl

Giancarlo Balercia

Nicolás Garrido Puchalt

Moncef Ben-Khalifa

Nicholas Tadros

Jackson Kirkman-Browne

Sergey Moskovtsev

Xuefeng Huang

Edson Borges Jr

Daniel Franken

Natan Bar-Chama

Yoshiharu Morimoto

Kazuhisa Tomita

Vasan Satya Srini

Willem Ombelet

Elisabetta Baldi

Monica Muratori

Yasushi Yumura

Sandro La Vignera

Raghavender Kosgi

Marlon P. Martinez

Donald P. Evenson

Daniel Suslik Zylbersztejn

Matheus Roque

Marcello Cocuzza

Marcelo Vieira

Assaf Ben-Meir

Raoul Orvieto

Eliahu Levitas

Amir Wiser

Mohamed Arafa

Vineet Malhotra

Sijo Joseph Parekattil

Haitham Elbardisi

Luiz Carvalho

Rima Dada

Christophe Sifer

Pankaj Talwar

Ahmet Gudeloglu

Ahmed M.A. Mahmoud

Khaled Terras

Chadi Yazbeck

Bojanic Nebojsa

Damayanthi Durairajanayagam

Ajina Mounir

Linda G. Kahn

Saradha Baskaran

Rishma Dhillon Pai

Donatella Paoli

Kristian Leisegang

Mohamed-Reza Moein

Sonia Malik

Onder Yaman

Luna Samanta

Fouad Bayane

Sunil K. Jindal

Muammer Kendirci

Baris Altay

Dragoljub Perovic

Avi Harlev

Format Sitasi

APA MLA BibTeX

Agarwal, A., Parekh, N., Selvam, M.K.P., Henkel, R., Shah, R., Homa, S.T. et al. (2019). Male Oxidative Stress Infertility (MOSI): Proposed Terminology and Clinical Practice Guidelines for Management of Idiopathic Male Infertility. https://doi.org/10.5534/wjmh.190055

@article{agarwal2019, author = {Ashok Agarwal and Neel Parekh and Manesh Kumar Panner Selvam and Ralf Henkel and Rupin Shah and Sheryl T. Homa and Ranjith Ramasamy and Edmund Ko and Kelton Tremellen and Sandro Esteves and Ahmad Majzoub and Juan G. Alvarez and David K. Gardner and Channa N. Jayasena and Jonathan W. Ramsay and Chak-Lam Cho and Ramadan Saleh and Denny Sakkas and James M. Hotaling and Scott D. Lundy and Sarah Vij and Joel Marmar and Jaime Gosalvez and Edmund Sabanegh and Hyun Jun Park and Armand Zini and Parviz Kavoussi and Sava Micic and Ryan Smith and Gian Maria Busetto and Mustafa Emre Bakırcıoğlu and Gerhard Haidl and Giancarlo Balercia and Nicolás Garrido Puchalt and Moncef Ben-Khalifa and Nicholas Tadros and Jackson Kirkman-Browne and Sergey Moskovtsev and Xuefeng Huang and Edson Borges Jr and Daniel Franken and Natan Bar-Chama and Yoshiharu Morimoto and Kazuhisa Tomita and Vasan Satya Srini and Willem Ombelet and Elisabetta Baldi and Monica Muratori and Yasushi Yumura and Sandro La Vignera and Raghavender Kosgi and Marlon P. Martinez and Donald P. Evenson and Daniel Suslik Zylbersztejn and Matheus Roque and Marcello Cocuzza and Marcelo Vieira and Assaf Ben-Meir and Raoul Orvieto and Eliahu Levitas and Amir Wiser and Mohamed Arafa and Vineet Malhotra and Sijo Joseph Parekattil and Haitham Elbardisi and Luiz Carvalho and Rima Dada and Christophe Sifer and Pankaj Talwar and Ahmet Gudeloglu and Ahmed M.A. Mahmoud and Khaled Terras and Chadi Yazbeck and Bojanic Nebojsa and Damayanthi Durairajanayagam and Ajina Mounir and Linda G. Kahn and Saradha Baskaran and Rishma Dhillon Pai and Donatella Paoli and Kristian Leisegang and Mohamed-Reza Moein and Sonia Malik and Onder Yaman and Luna Samanta and Fouad Bayane and Sunil K. Jindal and Muammer Kendirci and Baris Altay and Dragoljub Perovic and Avi Harlev}, title = {Male Oxidative Stress Infertility (MOSI): Proposed Terminology and Clinical Practice Guidelines for Management of Idiopathic Male Infertility}, year = {2019}, journal = {DOAJ}, doi = {10.5534/wjmh.190055}, }

Akses Cepat

PDF tidak tersedia langsung

doi.org/10.5534/wjmh.190055

Informasi Jurnal

Tahun Terbit: 2019
Sumber Database: DOAJ
DOI: 10.5534/wjmh.190055
Akses: Open Access ✓