The role of inflammatory marker and vitamin D deficiency in dyslipidemia

Background: The immunological and inflammatory systems are both modulated in large part by vitamin D. Lower vitamin D levels have been connected in several studies to an increased risk and worse course of acute infections. Many chronic diseases include inflammation, and concerns have been raised regarding how low vitamin D levels may affect inflammatory processes. Aim and Objective: Inflammatory markers and vitamin D levels in people with and without dyslipidemia were compared in this study. In addition, an effort was made to link the vitamin D levels of the research participants to the inflammatory alterations. Materials and Methods: A tertiary care teaching hospital conducted a cross-sectional study. A control population of 250 healthy, age- and sex-matched people without dyslipidemia was chosen, whereas 250 persons with dyslipidemia were included as test subjects. In the investigation of vitamin D, lipid profiles (total cholesterol, triglycerides, high-density lipoprotein, low-density lipoprotein, and very low density lipoprotein), and high-sensitivity C-reactive protein (hs-CRP), five milliliters of fasting blood samples from each individual were taken. Results: In comparison to the control groups, patients with dyslipidemia had significantly higher levels of hs-CRP and significantly lower levels of vitamin D. A statistically significant negative relationship between hs-CRP and vitamin D was revealed by the Pearson correlation. The deficiency of vitamin D may be root in the inflammation. Conclusion: People with dyslipidemia, hs-CRP levels are high and vitamin D levels are low. In test, population's low levels of vitamin D showed negative connection with hs-CRP, indicating that low vitamin D levels may aggravate the inflammatory response. [Natl J Physiol Pharm Pharmacol 2024; 14(4.000): 626-629]