The role of RhoA/ROCK singaling pathway in organoid research
Abstrak
Rho-associated coiled-coil containing protein kinase (ROCK) signaling is a primary regulator of cell behavior in stem cell biology and organoid systems. This review examines the diverse roles of Rho/ROCK signaling in cytoskeletal remodeling, cell adhesion, differentiation, and mechanotransduction. Special emphasis is placed on its role in organoid formation, patterning, and functional maturation. An understanding of how this pathway integrates with other signaling networks, such as Ras, Hippo, and PI3K-AKT, is crucial for optimizing organoid fidelity. We propose future research directions that enhance organoid models through targeted modulation of ROCK activity, thereby opening new opportunities for regenerative medicine and disease modeling.
Topik & Kata Kunci
Penulis (3)
Jung Hwa Lim
Hyun Mi Kang
Cho-Rok Jung
Akses Cepat
- Tahun Terbit
- 2025
- Sumber Database
- DOAJ
- DOI
- 10.51335/organoid.2025.5.e4
- Akses
- Open Access ✓