Allergic Bronchopulmonary Aspergillosis Unmasked: Case Series of Varied Pulmonary Presentations

Allergic bronchopulmonary aspergillosis (ABPA) is a complex hypersensitivity reaction to the fungus <i>Aspergillus fumigatus</i>, primarily affecting individuals with asthma or cystic fibrosis (CF). It is characterized by chronic inflammation, mucus plugging, and bronchiectasis. ABPA often presents with recurrent asthma exacerbations, fever, malaise, and productive cough. However, in rare instances, ABPA can manifest with atypical and severe clinical presentations, posing diagnostic challenges and requiring specialized management strategies. This case series explores three such rare presentations: ABPA with whole lung collapse, ABPA with type 2 respiratory failure, and ABPA mimicking malignancy. Recognizing these varied presentations and their underlying pathophysiological mechanisms is crucial for timely and accurate diagnosis. Early intervention with corticosteroids and antifungal therapy can significantly improve patient outcomes and prevent complications such as permanent lung damage. How to cite this article: Anand R, Pandiyan AS, Jayavignesh J, <i>et al.</i> Allergic Bronchopulmonary Aspergillosis Unmasked: Case Series of Varied Pulmonary Presentations. Indian J Respir Care 2025;14(2):133–136.