DOAJ Open Access 2023

Ferroptosis: a critical player and potential therapeutic target in traumatic brain injury and spinal cord injury

Qing-Sheng Li Yan-Jie Jia

Abstrak

Ferroptosis, a new non-necrotizing programmed cell death (PCD), is driven by iron-dependent phospholipid peroxidation. Ferroptosis plays a key role in secondary traumatic brain injury and secondary spinal cord injury and is closely related to inflammation, immunity, and chronic injuries. The inhibitors against ferroptosis effectively improve iron homeostasis, lipid metabolism, redox stabilization, neuronal remodeling, and functional recovery after trauma. In this review, we elaborate on the latest molecular mechanisms of ferroptosis, emphasize its role in secondary central nervous trauma, and update the medicines used to suppress ferroptosis following injuries.

Topik & Kata Kunci

Neurology. Diseases of the nervous system

Penulis (2)

Qing-Sheng Li

Yan-Jie Jia

Format Sitasi

APA MLA BibTeX

Li, Q., Jia, Y. (2023). Ferroptosis: a critical player and potential therapeutic target in traumatic brain injury and spinal cord injury. https://doi.org/10.4103/1673-5374.350187

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Informasi Jurnal

Tahun Terbit: 2023
Sumber Database: DOAJ
DOI: 10.4103/1673-5374.350187
Akses: Open Access ✓