DOAJ Open Access 2012

Preparation and evaluation of cilnidipine microemulsion

Hemal Tandel Krunal Raval Anil Nayani Manish Upadhay

Abstrak

Cilnidipine, a calcium channel blocker having neuroprotective action and BCS Class II drug, hence formulating in Microemulsion will increase solubility, absorption and bioavailability. The formulation was prepared using titration method by tocotrienol, tween 20 and transcutol HP as oil, surfactant and co-surfactant and characterized for dilutability, dye solubility, assay (98.39±0.06), pH (6.6±1.5), Viscosity (98±1.0 cps) and Conductivity (0.2±0.09 μS/cm). The formulation was optimized on basis of percentage transmittance (99.269±0.23 at 700 nm), Globule size (13.31±4.3 nm) and zeta potential (-11.4±2.3 mV). Cilnidipine microemulsion was found to be stable for 3 months.

Topik & Kata Kunci

Pharmacy and materia medica Analytical chemistry

Penulis (4)

Hemal Tandel

Krunal Raval

Anil Nayani

Manish Upadhay

Format Sitasi

APA MLA BibTeX

Tandel, H., Raval, K., Nayani, A., Upadhay, M. (2012). Preparation and evaluation of cilnidipine microemulsion. https://doi.org/10.4103/0975-7406.94162

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Informasi Jurnal

Tahun Terbit: 2012
Sumber Database: DOAJ
DOI: 10.4103/0975-7406.94162
Akses: Open Access ✓