DOAJ Open Access 2022

Research progress of NLRP3 inflammasome in the pathogenesis of psoriasis

Siman SHI Ju WEN Si QIN Wenbin HUANG Zhenyu LU

Abstrak

NLRP3 inflammasome activates IL-1β and IL-18. In recent years, a large number of in vitro and in vivo studies showed elevations in expression levels of NLRP3 inflammasome, IL-1β and IL-18 in psoriasis. The involvement of NLRP3 inflammasome in the pathogenesis of psoriasis may be related to the activation of NF-κB, P2X7, S1PR1 and miRNA155. Blocking NLRP3 inflammasome may affect AMPK and SIRT1 molecules as well as T cell signaling pathways in psoriasis models. Here we review the association of NLRP3 and psoriasis, the possible mechanisms by which NLRP3 regulates the progress of psoriasis and the changes in inflammatory pathway after blockade of NLRP3.

Topik & Kata Kunci

Dermatology

Penulis (5)

Siman SHI

Ju WEN

Si QIN

Wenbin HUANG

Zhenyu LU

Format Sitasi

APA MLA BibTeX

SHI, S., WEN, J., QIN, S., HUANG, W., LU, Z. (2022). Research progress of NLRP3 inflammasome in the pathogenesis of psoriasis. https://doi.org/10.3969/j.issn.1674-8468.2022.05.017

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Informasi Jurnal

Tahun Terbit: 2022
Sumber Database: DOAJ
DOI: 10.3969/j.issn.1674-8468.2022.05.017
Akses: Open Access ✓