Clopidogrel sticking issue: a systematic review on factors and formulation assessment
Abstrak
Since the expiry of the originator’s patent related to clopidogrel in 2012, generic drugs have been extensively manufactured worldwide. However, numerous operational concerns have started to emerge within many pharmaceutical industries. One major concern commonly reported is the problem of tablet formulations adhering to punches and dies during compression. This defect has directed substantial research efforts toward addressing the issue, ranging from root cause analysis to full implementation of solutions. A systematic review was therefore an essential prerequisite to identify, from the literature, the most critical attributes contributing to this defect in order to achieve sticking-free tableting. Data were extracted from patents and reputed scientific articles. Records were assessed based on scientific knowledge, whereby recommendations for future research were subsequently provided.
Topik & Kata Kunci
Penulis (1)
Hiba Hani Mohammed Ali
Akses Cepat
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- 2025
- Sumber Database
- DOAJ
- DOI
- 10.3897/pharmacia.72.e175279
- Akses
- Open Access ✓