DOAJ Open Access 2022

Use of off-label compounded oral sildenafil in the management of persistent pulmonary hypertension of the newborn: A case report

Olapeju Daniyan Obumneme Ezeanosike Dorathy Obu Fortune Ujunwa

Lihat Sumber DOI

Abstrak

We report a case of a newborn with persistent pulmonary hypertension (PPHN) due to meconium aspiration syndrome with associated lung collapse. Echocardiogram revealed features of persistent pulmonary hypertension. He was treated with compounded oral sildenafil. Oral sildenafil has proven to be effective and safe in the management of PPHN in neonates with persistent pulmonary hypertension. Therefore, in situations where inhaled nitric oxide is not available it may be used as an alternative therapy in PPHN. Further randomized controlled studies are needed to determine its efficacy and pharmacokinetics.

Topik & Kata Kunci

Diseases of the circulatory (Cardiovascular) system

Penulis (4)

Olapeju Daniyan

Obumneme Ezeanosike

Dorathy Obu

Fortune Ujunwa

Format Sitasi

APA MLA BibTeX

Daniyan, O., Ezeanosike, O., Obu, D., Ujunwa, F. (2022). Use of off-label compounded oral sildenafil in the management of persistent pulmonary hypertension of the newborn: A case report. https://doi.org/10.34172/jcvtr.2022.03

Akses Cepat

Lihat di Sumber doi.org/10.34172/jcvtr.2022.03

Informasi Jurnal

Tahun Terbit: 2022
Sumber Database: DOAJ
DOI: 10.34172/jcvtr.2022.03
Akses: Open Access ✓