DOAJ Open Access 2022

MRI CNS Atrophy Pattern and the Etiologies of Progressive Ataxias

Mario Mascalchi

Abstrak

MRI shows the three archetypal patterns of CNS volume loss underlying progressive ataxias in vivo, namely spinal atrophy (SA), cortical cerebellar atrophy (CCA) and olivopontocerebellar atrophy (OPCA). The MRI-based CNS atrophy pattern was reviewed in 128 progressive ataxias. A CNS atrophy pattern was identified in 91 conditions: SA in Friedreich’s ataxia, CCA in 5 acquired and 72 (24 dominant, 47 recessive,1 X-linked) inherited ataxias, OPCA in Multi-System Atrophy and 12 (9 dominant, 2 recessive,1 X-linked) inherited ataxias. The MRI-based CNS atrophy pattern may be useful for genetic assessment, identification of shared cellular targets, repurposing therapies or the enlargement of drug indications in progressive ataxias.

Topik & Kata Kunci

Computer applications to medicine. Medical informatics

Penulis (1)

Mario Mascalchi

Format Sitasi

APA MLA BibTeX

Mascalchi, M. (2022). MRI CNS Atrophy Pattern and the Etiologies of Progressive Ataxias. https://doi.org/10.3390/tomography8010035

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Informasi Jurnal

Tahun Terbit: 2022
Sumber Database: DOAJ
DOI: 10.3390/tomography8010035
Akses: Open Access ✓