DOAJ Open Access 2018

Cavitation-Assisted Micromixing for Polymeric Nanoparticle Generation

Salvatore Surdo Mike Alexander Geven Roberto Donno Alberto Diaspro Nicola Tirelli +1 lainnya

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Abstrak

The high-throughput generation of polymeric nanoparticles (PNPs) with tailored size and narrow size distribution is key for applications as relevant as sensing and nanomedicine. Here we show how cavitation bubbles in a microfluidic channel can induce rapid nanoprecipitation of PNPs with user-selectable control. Specifically, we used two tip-electrodes perpendicular to the flow to induce electrical breakdown of a polymer solution and a miscible non-solvent. As a result, a plasma is formed causing cavitation and rapid mixing of the fluids, yielding nanoprecipitates of polymer. We demonstrated mL/min generation of PNPs with a diameter as low as 150 nm and polydispersity below 0.15.

Topik & Kata Kunci

General Works

Penulis (6)

Salvatore Surdo

Mike Alexander Geven

Roberto Donno

Alberto Diaspro

Nicola Tirelli

Martí Duocastella

Format Sitasi

APA MLA BibTeX

Surdo, S., Geven, M.A., Donno, R., Diaspro, A., Tirelli, N., Duocastella, M. (2018). Cavitation-Assisted Micromixing for Polymeric Nanoparticle Generation. https://doi.org/10.3390/proceedings2130942

Akses Cepat

Lihat di Sumber doi.org/10.3390/proceedings2130942

Informasi Jurnal

Tahun Terbit: 2018
Sumber Database: DOAJ
DOI: 10.3390/proceedings2130942
Akses: Open Access ✓