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DOAJ Open Access 2023

First-Row Transition 7-Oxo-5-phenyl-1,2,4-triazolo[1,5-a]pyrimidine Metal Complexes: Antiparasitic Activity and Release Studies

Álvaro Martín-Montes Sandra Jimenez-Falcao Santiago Gómez-Ruiz Clotilde Marín José M. Mendez-Arriaga
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Abstrak

Leishmaniasis and Chagas disease are still considered neglected illnesses due to the lack of investment in research, despite the fact that almost one million new cases are reported every year. Four 7-oxo-5-phenyl-1,2,4-triazolo[1,5-a]pyrimidine (HftpO) first-row transition complexes (Cu, Co, Ni, Zn) have been studied for the first time in vitro against five different species of <i>Leishmania</i> spp. (<i>L. infantum</i>, <i>L. braziliensis</i>, <i>L. donovani</i>, <i>L. peruviana</i> and <i>L. mexicana</i>) as well as <i>Trypanosoma cruzi</i>, showing higher efficacy than the reference commercial drugs. UV and luminescence properties were also evaluated. As a proof of concept, anchoring of a model high-effective-metal complex as an antiparasitic agent on silica nanoparticles was carried out for the first time, and drug-release behaviour was evaluated, assessing this new approach for drug vehiculation.

Topik & Kata Kunci

Medicine Pharmacy and materia medica

Penulis (5)

Á

Álvaro Martín-Montes

S

Sandra Jimenez-Falcao

S

Santiago Gómez-Ruiz

C

Clotilde Marín

J

José M. Mendez-Arriaga

Format Sitasi

APA MLA BibTeX
Martín-Montes, Á., Jimenez-Falcao, S., Gómez-Ruiz, S., Marín, C., Mendez-Arriaga, J.M. (2023). First-Row Transition 7-Oxo-5-phenyl-1,2,4-triazolo[1,5-a]pyrimidine Metal Complexes: Antiparasitic Activity and Release Studies. https://doi.org/10.3390/ph16101380

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Informasi Jurnal
Tahun Terbit
2023
Sumber Database
DOAJ
DOI
10.3390/ph16101380
Akses
Open Access ✓