Magnetic Resonance Imaging and X-Ray Imaging Properties of Ultrasmall Lanthanide Oxide (Ln = Eu, Gd, and Tb) Nanoparticles Synthesized via Thermal Decomposition
Abstrak
Owing to their 4f electrons and high atomic numbers, lanthanide (Ln) elements impart lanthanide oxide (Ln<sub>2</sub>O<sub>3</sub>) nanoparticles with excellent biomedical imaging properties. This study reports synthesis for three types of ultrasmall and monodisperse Ln<sub>2</sub>O<sub>3</sub> nanoparticles (Ln = Eu, Gd, and Tb) via thermal decomposition in oleylamine at 280 °C, followed by ligand exchange with citric acid (CA) to produce water-dispersible, CA-grafted Ln<sub>2</sub>O<sub>3</sub> nanoparticles with high colloidal stability. The resulting CA-grafted Ln<sub>2</sub>O<sub>3</sub> nanoparticles had average diameters of approximately 2 nm. We characterized their physicochemical properties, including in vitro cytotoxicity, magnetic resonance imaging properties (i.e., water proton spin relaxivities), and X-ray imaging properties (i.e., X-ray attenuation).
Topik & Kata Kunci
Penulis (16)
Shuwen Liu
Tirusew Tegafaw
Son Long Ho
Huan Yue
Dejun Zhao
Ying Liu
Endale Mulugeta
Xiaoran Chen
Hansol Lee
Dabin Ahn
Ji-ung Yang
Ji Ae Park
Ahrum Baek
Jihyun Kim
Yongmin Chang
Gang Ho Lee
Format Sitasi
Akses Cepat
- Tahun Terbit
- 2025
- Sumber Database
- DOAJ
- DOI
- 10.3390/molecules30122519
- Akses
- Open Access ✓