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DOAJ Open Access 2024

A Novel Benzothiazole-Based Fluorescent AIE Probe for the Detection of Hydrogen Peroxide in Living Cells

Dezhi Shi Yulong Yang Luan Tong Likang Zhang Fengqing Yang +2 lainnya
Lihat Sumber DOI

Abstrak

A benzothiazole-based derivative aggregation-induced emission (AIE) fluorescent ‘turn-on’ probe named 2-(2-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)oxy)phenyl)benzo[<i>d</i>]thiazole (probe <b>BT-BO</b>) was developed and synthesized successfully for detecting hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) in living cells. The synthesis method of probe <b>BT-BO</b> is facile. Probe <b>BT-BO</b> demonstrates a well-resolved emission peak at 604 nm and the ability to prevent the interference of reactive oxygen species (ROS), various metal ions and anion ions, and good sensitivity. Additionally, the probe boasts impressive pH range versatility, a fast response time to H<sub>2</sub>O<sub>2</sub> and low cytotoxicity. Finally, probe <b>BT-BO</b> was applied successfully to image A549 and Hep G2 cells to monitor both exogenous and endogenous H<sub>2</sub>O<sub>2</sub>.

Topik & Kata Kunci

Organic chemistry

Penulis (7)

D

Dezhi Shi

Y

Yulong Yang

L

Luan Tong

L

Likang Zhang

F

Fengqing Yang

J

Jiali Tao

M

Mingxia Zhao

Format Sitasi

APA MLA BibTeX
Shi, D., Yang, Y., Tong, L., Zhang, L., Yang, F., Tao, J. et al. (2024). A Novel Benzothiazole-Based Fluorescent AIE Probe for the Detection of Hydrogen Peroxide in Living Cells. https://doi.org/10.3390/molecules29215181

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Informasi Jurnal
Tahun Terbit
2024
Sumber Database
DOAJ
DOI
10.3390/molecules29215181
Akses
Open Access ✓