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DOAJ Open Access 2024

Stereodivergent Synthesis of Aldol Products Using Pseudo-C<sub>2</sub> Symmetric <i>N</i>-benzyl-4-(trifluoromethyl)piperidine-2,6-dione

Rina Yada Tomoko Kawasaki-Takasuka Takashi Yamazaki
Lihat Sumber DOI

Abstrak

The present article describes the successful performance of crossed aldol reactions of the CF<sub>3</sub>-containing pseudo-C<sub>2</sub> symmetric cyclic imide with various aldehydes. The utilization of HMPA as an additive attained the preferential formation of the <i>anti</i>-products in good to excellent yields, which contrasts with our previous method without this additive, proceeding to furnish the corresponding <i>syn</i>-isomers. The effective participation of ketones and α,β-unsaturated carbonyl compounds in reactions with this imide was also demonstrated to expand the application of this imide.

Topik & Kata Kunci

Organic chemistry

Penulis (3)

R

Rina Yada

T

Tomoko Kawasaki-Takasuka

T

Takashi Yamazaki

Format Sitasi

APA MLA BibTeX
Yada, R., Kawasaki-Takasuka, T., Yamazaki, T. (2024). Stereodivergent Synthesis of Aldol Products Using Pseudo-C<sub>2</sub> Symmetric <i>N</i>-benzyl-4-(trifluoromethyl)piperidine-2,6-dione. https://doi.org/10.3390/molecules29215129

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Lihat di Sumber doi.org/10.3390/molecules29215129
Informasi Jurnal
Tahun Terbit
2024
Sumber Database
DOAJ
DOI
10.3390/molecules29215129
Akses
Open Access ✓