DOAJ Open Access 2011

Synthesis and Structural Characterization of 1-[2-(5-Nitro-1H-indol-2-yl)phenyl]methylpyridinium Chloride

John B. Bremner Siritron Samosorn Brian W. Skelton Allan H. White

Abstrak

In the course of studies on hybrid antibacterials incorporating 2-aryl-5-nitro-1H-indole moieties as potential bacterial NorA efflux pump inhibitors, the compound 1-[2-(5-nitro-1H-indol-2-yl)phenyl]methylpyridinium chloride (2) was synthesized and structurally characterized. This pyridinium chloride salt crystallized in the monoclinic space group P21/c with the following unit cell dimensions: a 10.274(3) Å, b 13.101(4) Å, c 13.439(4) Å, b 107.702(7)°, V 1723.2(9) Å3, Z (f.u.) = 4; R1 = 0.048, and wR2 = 0.13. Of interest in the single crystal X-ray structure is the (intramolecular) disposition of the pyridinium plane over the indole heterocyclic residue [interplanar dihedral angle 17.91(4)°].

Topik & Kata Kunci

Organic chemistry

Penulis (4)

John B. Bremner

Siritron Samosorn

Brian W. Skelton

Allan H. White

Format Sitasi

APA MLA BibTeX

Bremner, J.B., Samosorn, S., Skelton, B.W., White, A.H. (2011). Synthesis and Structural Characterization of 1-[2-(5-Nitro-1H-indol-2-yl)phenyl]methylpyridinium Chloride. https://doi.org/10.3390/molecules16097627

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Informasi Jurnal

Tahun Terbit: 2011
Sumber Database: DOAJ
DOI: 10.3390/molecules16097627
Akses: Open Access ✓