The Effect of Music Therapy on Psychological Outcomes for Neurological Conditions: A Systematic Review

<i>Background and Objectives:</i> Music therapy has been used as a non-pharmacological treatment for neurological conditions, supporting cognitive, psychosocial, behavioural and motor functions. Although it is evidence-based, safe, and cost-effective, music therapy remains uncommon in neurorehabilitation services, largely due to a lack of quality research. This review aims to understand the effect of music therapy on psychological outcomes for neurological conditions using randomised clinical trials (RCTs). <i>Materials and Methods:</i> A systematic review of literature published in four databases (PsycINFO, CINAHL, PubMed, and Scopus which is inclusive of Medline and EMBASE) from 1 January 2015 to 31 January 2025 was performed. <i>Results:</i> Ten RCT’s comprising 469 participants were included in this review, with seven studies synthesised using a systematic review without meta-analysis approach. MT was found to improve cognitive function in individuals with Parkinson’s disease (PD) and Traumatic Brain Injury (TBI), but not in those with stroke or Huntington’s disease (HD). In HD, improvements in cognitive function were noted in the comparator group. MT led to significant improvements in emotional well-being in stroke survivors, though not in mood. Behavioural outcomes did not significantly improve in HD, while quality of life improved following MT for individuals with multiple sclerosis (MS) and stroke. <i>Conclusions:</i> Overall, MT was perceived as a positive intervention with potential psychological benefits. However, findings were mixed, and the heterogeneity of population, intervention, comparator, outcomes, and study design limited the ability to detect group differences and reduced confidence in the findings. Future research should focus on larger-scale RCTs that reduce bias, accommodate population diversity, and clearly define and distinguish MT from treatment-as-usual. Better standardisation of outcomes and improved reporting will be essential to evaluate the efficacy of music therapy in neurological conditions and strengthen the evidence base for its use in clinical practice.