Toward a Blood Sensor for an IoT Monitoring: A New Approach for the Design and Implementation of Blood Light Absorption Systems Based on the Finite Element Method and the Diffusion Equation

Non-invasive blood analysis has the power to completely change how doctors identify and track illnesses. This study presents a novel approach for the non-invasive monitoring of red blood cell (RBC) mobility and concentration within capillaries, using photon absorption as a key diagnostic tool. The research combines optical modeling with the diffusion equation for light propagation, leveraging COMSOL simulations to create a comprehensive framework for understanding RBC dynamics. A two-dimensional geometric model of capillaries with RBCs is developed, where blood flow is modeled as a laminar, incompressible fluid. The Arbitrary Lagrangian–Eulerian (ALE) formulation is employed to account for the fluid–structure interactions, while photon attenuation by the RBCs is analyzed to investigate wavelength-dependent absorption characteristics. The methodology is implemented through a workflow developed with MATLAB’s S-Function builder, consisting of three main components: mesh generation, fluence computing, and Software-in-the-Loop (SIL) verification. The mesh generation process adapts to the target architecture using COMSOL Multiphysics for fluid–structure interaction (FSI) modeling. The fluence computing function solves the diffusion equation to model light intensity attenuation due to RBCs, and the SIL function compares computed results with real-time measurements, ensuring accuracy for potential real-time embedded system applications. The results demonstrate significant wavelength-dependent variations in photon absorption by RBCs, providing insights into the optical behavior of blood in microvascular structures. The findings have important implications for medical imaging, photodynamic therapy, and diagnostic tools, emphasizing the potential of integrating computational models with real-time systems for enhanced performance in biomedical applications.