DOAJ Open Access 2020

Comparative Study of Contact Repulsion in Control and Mutant Macrophages Using a Novel Interaction Detection

José Alonso Solís-Lemus Besaiz J Sánchez-Sánchez Stefania Marcotti Mubarik Burki Brian Stramer +1 lainnya

Abstrak

In this paper, a novel method for interaction detection is presented to compare the contact dynamics of macrophages in the <i>Drosophila</i> embryo. The study is carried out by a framework called macrosight, which analyses the movement and interaction of migrating macrophages. The framework incorporates a segmentation and tracking algorithm into analysing the motion characteristics of cells after contact. In this particular study, the interactions between cells is characterised in the case of control embryos and <i>Shot</i> mutants, a candidate protein that is hypothesised to regulate contact dynamics between migrating cells. Statistical significance between control and mutant cells was found when comparing the direction of motion after contact in specific conditions. Such discoveries provide insights for future developments in combining biological experiments with computational analysis.

Topik & Kata Kunci

Photography Computer applications to medicine. Medical informatics Electronic computers. Computer science

Penulis (6)

José Alonso Solís-Lemus

Besaiz J Sánchez-Sánchez

Stefania Marcotti

Mubarik Burki

Brian Stramer

Constantino Carlos Reyes-Aldasoro

Format Sitasi

APA MLA BibTeX

Solís-Lemus, J.A., Sánchez-Sánchez, B.J., Marcotti, S., Burki, M., Stramer, B., Reyes-Aldasoro, C.C. (2020). Comparative Study of Contact Repulsion in Control and Mutant Macrophages Using a Novel Interaction Detection. https://doi.org/10.3390/jimaging6050036

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Informasi Jurnal

Tahun Terbit: 2020
Sumber Database: DOAJ
DOI: 10.3390/jimaging6050036
Akses: Open Access ✓