<i>Aloe vera</i>-Based Hydrogels for Wound Healing: Properties and Therapeutic Effects

<i>Aloe vera</i>-based hydrogels have emerged as promising platforms for the delivery of therapeutic agents in wound dressings due to their biocompatibility and unique wound-healing properties. The present study provides a comprehensive overview of recent advances in the application of <i>Aloe vera</i>-based hydrogels for wound healing. The synthesis methods, structural characteristics, and properties of <i>Aloe vera</i>-based hydrogels are discussed. Mechanisms of therapeutic agents released from <i>Aloe vera</i>-based hydrogels, including diffusion, swelling, and degradation, are also analyzed. In addition, the therapeutic effects of <i>Aloe vera</i>-based hydrogels on wound healing, as well as the reduction of inflammation, antimicrobial activity, and tissue regeneration, are highlighted. The incorporation of various therapeutic agents, such as antimicrobial and anti-inflammatory ones, into <i>Aloe vera</i>-based hydrogels is reviewed in detail. Furthermore, challenges and future prospects of <i>Aloe vera</i>-based hydrogels for wound dressing applications are considered. This review provides valuable information on the current status of <i>Aloe vera</i>-based hydrogels for the delivery of therapeutic agents in wound dressings and highlights their potential to improve wound healing outcomes.