DOAJ Open Access 2024

Dynamic Covalent Boronic-Acid-Functionalized Alginate/PVA Hydrogels for pH and Shear-Responsive Drug Delivery

Yessenia Oyarzún José Ulloa Matías Ceballos Bruno F. Urbano

Abstrak

Herein, we investigated hydrogels composed of boronic-acid-functionalized alginate and blended with polyvinyl alcohol (PVA) of different molecular weights to control the release of metoclopramide hydrochloride as a function of pH and shear stress. The functionalization of alginate introduced dynamic covalent bonding and pH-responsive properties that can modulate network connectivity. The study investigated the viscoelastic properties of the hydrogels, their drug release profiles, and their responsiveness to changes in pH and shear forces. The results showed that a higher PVA molecular weight and alkaline pH conditions increased hydrogel viscosity and stiffness due to a more stable and interconnected network structure than acidic pH. Metoclopramide release revealed that the hydrogels exhibited pH-responsive drug release behavior. The drug was more readily released under acidic conditions due to the instability of sp<sup>2</sup>-hybridized boronate ester bonds. The influence of shear forces on the release of metoclopramide was also investigated at shear rates of 1, 10, and 100 s<sup>−1</sup>, revealing their effect on matrix stiffening. Research shows that AlgBA/PVA hydrogels have unique properties, such as dynamic covalent bonding, that make them sensitive to external mechanical forces. This sensitivity makes them ideal for applications where physiological conditions trigger drug release.

Penulis (4)

Y

Yessenia Oyarzún

J

José Ulloa

M

Matías Ceballos

B

Bruno F. Urbano

Format Sitasi

Oyarzún, Y., Ulloa, J., Ceballos, M., Urbano, B.F. (2024). Dynamic Covalent Boronic-Acid-Functionalized Alginate/PVA Hydrogels for pH and Shear-Responsive Drug Delivery. https://doi.org/10.3390/gels10080504

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Informasi Jurnal
Tahun Terbit
2024
Sumber Database
DOAJ
DOI
10.3390/gels10080504
Akses
Open Access ✓