DOAJ Open Access 2020

Exosomes: From Potential Culprits to New Therapeutic Promise in the Setting of Cardiac Fibrosis

Roman Tikhomirov Benedict Reilly-O’ Donnell Francesco Catapano Giuseppe Faggian Julia Gorelik +2 lainnya

Lihat Sumber DOI

Abstrak

Fibrosis is a significant global health problem associated with many inflammatory and degenerative diseases affecting multiple organs, individually or simultaneously. Fibrosis develops when extracellular matrix (ECM) remodeling becomes excessive or uncontrolled and is associated with nearly all forms of heart disease. Cardiac fibroblasts and myofibroblasts are the main effectors of ECM deposition and scar formation. The heart is a complex multicellular organ, where the various resident cell types communicate between themselves and with cells of the blood and immune systems. Exosomes, which are small extracellular vesicles, (EVs), contribute to cell-to-cell communication and their pathophysiological relevance and therapeutic potential is emerging. Here, we will critically review the role of endogenous exosomes as possible fibrosis mediators and discuss the possibility of using stem cell-derived and/or engineered exosomes as anti-fibrotic agents.

Topik & Kata Kunci

Cytology

Penulis (7)

Roman Tikhomirov

Benedict Reilly-O’ Donnell

Francesco Catapano

Giuseppe Faggian

Julia Gorelik

Fabio Martelli

Costanza Emanueli

Format Sitasi

APA MLA BibTeX

Tikhomirov, R., Donnell, B.R., Catapano, F., Faggian, G., Gorelik, J., Martelli, F. et al. (2020). Exosomes: From Potential Culprits to New Therapeutic Promise in the Setting of Cardiac Fibrosis. https://doi.org/10.3390/cells9030592

Akses Cepat

Lihat di Sumber doi.org/10.3390/cells9030592

Informasi Jurnal

Tahun Terbit: 2020
Sumber Database: DOAJ
DOI: 10.3390/cells9030592
Akses: Open Access ✓