DOAJ Open Access 2023

Imaging Carotid Plaque Inflammation Using Positron Emission Tomography: Emerging Role in Clinical Stroke Care, Research Applications, and Future Directions

John J. McCabe Nicholas R. Evans Sarah Gorey Shiv Bhakta James H. F. Rudd +1 lainnya

Abstrak

Atherosclerosis is a chronic systemic inflammatory condition of the vasculature and a leading cause of stroke. Luminal stenosis severity is an important factor in determining vascular risk. Conventional imaging modalities, such as angiography or duplex ultrasonography, are used to quantify stenosis severity and inform clinical care but provide limited information on plaque biology. Inflammatory processes are central to atherosclerotic plaque progression and destabilization. 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a validated technique for quantifying plaque inflammation. In this review, we discuss the evolution of FDG-PET as an imaging modality to quantify plaque vulnerability, challenges in standardization of image acquisition and analysis, its potential application to routine clinical care after stroke, and the possible role it will play in future drug discovery.

Topik & Kata Kunci

Cytology

Penulis (6)

John J. McCabe

Nicholas R. Evans

Sarah Gorey

Shiv Bhakta

James H. F. Rudd

Peter J. Kelly

Format Sitasi

APA MLA BibTeX

McCabe, J.J., Evans, N.R., Gorey, S., Bhakta, S., Rudd, J.H.F., Kelly, P.J. (2023). Imaging Carotid Plaque Inflammation Using Positron Emission Tomography: Emerging Role in Clinical Stroke Care, Research Applications, and Future Directions. https://doi.org/10.3390/cells12162073

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Informasi Jurnal

Tahun Terbit: 2023
Sumber Database: DOAJ
DOI: 10.3390/cells12162073
Akses: Open Access ✓