DOAJ Open Access 2021

Inflammasomes and Colorectal Cancer

Sanaz Keshavarz Shahbaz Khadijeh Koushki Seyed Hassan Ayati Abigail R. Bland Evgeny E. Bezsonov +1 lainnya

Abstrak

Inflammasomes are important intracellular multiprotein signaling complexes that modulate the activation of caspase-1 and induce levels of the proinflammatory cytokines interleukin-1β (IL-1β) and IL-18 in response to pathogenic microorganisms and molecules that originated from host proteins. Inflammasomes play contradictory roles in the development of inflammation-induced cancers. Based on several findings, inflammasomes can initiate and promote carcinogenesis. On the contrary, inflammasomes also exhibit anticancer effects by triggering pyroptosis and immunoregulatory functions. Herein, we review extant studies delving into different functions of inflammasomes in colorectal cancer development.

Topik & Kata Kunci

Penulis (6)

S

Sanaz Keshavarz Shahbaz

K

Khadijeh Koushki

S

Seyed Hassan Ayati

A

Abigail R. Bland

E

Evgeny E. Bezsonov

A

Amirhossein Sahebkar

Format Sitasi

Shahbaz, S.K., Koushki, K., Ayati, S.H., Bland, A.R., Bezsonov, E.E., Sahebkar, A. (2021). Inflammasomes and Colorectal Cancer. https://doi.org/10.3390/cells10092172

Akses Cepat

PDF tidak tersedia langsung

Cek di sumber asli →
Lihat di Sumber doi.org/10.3390/cells10092172
Informasi Jurnal
Tahun Terbit
2021
Sumber Database
DOAJ
DOI
10.3390/cells10092172
Akses
Open Access ✓