Structural Modification of Epigallocatechin-3-gallate to (2<i>R</i>,3<i>R</i>)-5,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)chroman-3-yl <span style="font-variant: small-caps">l</span>-valinate in Four Steps
Abstrak
Tea is a daily drink for most people, and one of its major ingredients, epigallocatechin-3-gallate (EGCG), has been widely recognized as a potent antioxidant with diverse biological activities. However, its low stability and bioavailability hinder its further clinical applications. In this study, we designed and synthesized a novel EGCG-valine derivative <b>4</b> by replacing the gallic acid with a valine moiety in four steps. The structural elucidation of derivative <b>4</b> was performed using NMR, IR, mass, and UV spectroscopies. Additionally, the physicochemical properties of <b>4</b> were predicted by SwissADME, showing improved drug-like parameters and intestinal absorption compared to the parent compound EGCG.
Topik & Kata Kunci
Penulis (4)
Xiaoman Yu
Zimo Ren
Paolo Coghi
Jerome P. L. Ng
Format Sitasi
Akses Cepat
- Tahun Terbit
- 2024
- Sumber Database
- DOAJ
- DOI
- 10.3390/M1826
- Akses
- Open Access ✓