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DOAJ Open Access 2024

Three-Step Synthesis of <i>N</i>-(7-chloro-4-morpholinoquinolin-2-yl)benzamide from 4,7-Dichloroquinoline

Deiby F. Aparicio Acevedo Marlyn C. Ortiz Villamizar Vladimir V. Kouznetsov
Lihat Sumber DOI

Abstrak

The quinoline derivative, <i>N</i>-(7-chloro-4-morpholinoquinolin-2-yl)benzamide, was synthesized in a conventional three-step procedure from 4,7-dichloroquinoline using a <i>N</i>-oxidation reaction/C2-amide formation reaction/C4 S<sub>N</sub>Ar reaction sequence. The structure of the compound was fully characterized by FT-IR, <sup>1</sup>H-, <sup>13</sup>C-NMR, DEPT-135°, and ESI-MS techniques. Its physicochemical parameters (Lipinski’s descriptors) were also calculated using the online SwissADME database. Such derivatives are relevant therapeutic agents exhibiting potent anticancer, antibacterial, antifungal, and antiparasitic properties.

Topik & Kata Kunci

Inorganic chemistry

Penulis (3)

D

Deiby F. Aparicio Acevedo

M

Marlyn C. Ortiz Villamizar

V

Vladimir V. Kouznetsov

Format Sitasi

APA MLA BibTeX
Acevedo, D.F.A., Villamizar, M.C.O., Kouznetsov, V.V. (2024). Three-Step Synthesis of <i>N</i>-(7-chloro-4-morpholinoquinolin-2-yl)benzamide from 4,7-Dichloroquinoline. https://doi.org/10.3390/M1796

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Informasi Jurnal
Tahun Terbit
2024
Sumber Database
DOAJ
DOI
10.3390/M1796
Akses
Open Access ✓