DOAJ Open Access 2025

Exposure to deltamethrin leads to gill liver damage, oxidative stress, inflammation, and metabolic disorders of Japanese flounder (Paralichthys olivaceus)

Bingbu Li Bingbu Li Bingbu Li Guixing Wang Guixing Wang +41 lainnya

Abstrak

IntroductionDeltamethrin is a pyrethroid insecticide commonly used to kill animal parasites in aquaculture. However, increasing evidence suggests that deltamethrin affects the health of aquatic animals by causing tissue damage and even death.MethodsIn this study, the damage caused by deltamethrin to the gill and liver tissues, as well as its effects on oxidative stress and immune metabolism, were studied in Paralichthys olivaceus.ResultsWe observed a positive correlation between the residual levels of deltamethrin (Del) and the exposure concentrations, with the highest residue detected in the 0.28 μg/L concentration group (0.0684 mg/kg at 7 days). Then, we observed different degrees of damage to the gill and liver tissues of the Paralichthys olivaceus, including swelling, apical fusion, shedding of gill secondary lamellae, liver cell necrosis, and nuclear vacuolization, by observing tissue sections. Lysozyme enzyme activity increased, whereas catalase and alkaline phosphatase enzyme activities decreased. The liver transcriptome results of the control and high-concentration (0.28 μg/L) groups showed that there were 697 differentially expressed genes, including 390 upregulated and 307 downregulated genes. These differentially expressed genes were significantly enriched in oxidation-reduction, ferroptosis, steroid biosynthesis, and apoptosis pathways.DiscussionIn summary, we found that deltamethrin induces oxidative stress and metabolic disorders in P. olivaceus and leads to inflammation. However, the fish body resists such damage through a complex regulatory network. These experimental results provide a theoretical reference for the safe use of deltamethrin in P. olivaceus.

Topik & Kata Kunci

Toxicology. Poisons

Penulis (46)

Bingbu Li

Guixing Wang

Xinyu Zheng

Mingyang Liu

Yucong Yang

Yuqin Ren

Yitong Zhang

Yufeng Liu

Zhongwei He

Jiangong Ren

Hailong Wan

Wei Cao

Yufen Wang

Xiaoyan Zhang

Jilun Hou

Format Sitasi

APA MLA BibTeX

Li, B., Li, B., Li, B., Wang, G., Wang, G., Wang, G. et al. (2025). Exposure to deltamethrin leads to gill liver damage, oxidative stress, inflammation, and metabolic disorders of Japanese flounder (Paralichthys olivaceus). https://doi.org/10.3389/ftox.2025.1560192

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Informasi Jurnal

Tahun Terbit: 2025
Sumber Database: DOAJ
DOI: 10.3389/ftox.2025.1560192
Akses: Open Access ✓