DOAJ Open Access 2018

Age-Related Changes in Human Schlemm’s Canal: An in Vivo Optical Coherence Tomography-Based Study

Yujin Zhao Junyi Chen Xiaobo Yu Jianjiang Xu Xinghuai Sun +4 lainnya

Abstrak

Purpose: To investigate age-related changes in human Schlemm’s canal (SC) using spectral-domain optical coherence tomography (SD-OCT).Methods: A total of 125 normal eyes were imaged using SD-OCT nasally and temporally. The age-related variations of SC sagittal diameter and cross-sectional area (CSA) from four age groups [A (16–20 years), B (21–40 years), C (41–60 years), and D (61–80 years)] were analyzed with Spearman correlation.Results: The positive detection rates of SC showed a significantly downward trend with age. The mean CSA was 13,296 ± 1,897 μm2 nasally and 14,552 ± 2,589 μm2 temporally. The mean CSA was significantly larger in the temporal than in the nasal region (P < 0.05). Nasal CSA values varied among the four age groups (P = 0.004).Conclusion: Our study found for the first time that SC in vivo exhibits a morphological variant with age in healthy humans. Clinicians may need to consider this phenomenon when performing examinations targeting SC for glaucoma patients.

Topik & Kata Kunci

Physiology

Penulis (9)

Yujin Zhao

Junyi Chen

Xiaobo Yu

Jianjiang Xu

Xinghuai Sun

Jiaxu Hong

Format Sitasi

APA MLA BibTeX

Zhao, Y., Chen, J., Yu, X., Xu, J., Sun, X., Hong, J. et al. (2018). Age-Related Changes in Human Schlemm’s Canal: An in Vivo Optical Coherence Tomography-Based Study. https://doi.org/10.3389/fphys.2018.00630

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Informasi Jurnal

Tahun Terbit: 2018
Sumber Database: DOAJ
DOI: 10.3389/fphys.2018.00630
Akses: Open Access ✓