DOAJ Open Access 2025

Potential therapeutic targets for ischemic stroke in pre-clinical studies: Epigenetic-modifying enzymes DNMT/TET and HAT/HDAC

Yurou Guo Jing Li Xiaodan Liu Xiaodan Liu Huang Ding +3 lainnya

Abstrak

Ischemic stroke (IS) remains a leading cause of mortality and disability worldwide, driven by genetic predispositions and environmental interactions, with epigenetics playing a pivotal role in mediating these processes. Specific modifying enzymes that regulate epigenetic changes have emerged as promising targets for IS treatment. DNA methyltransferases (DNMTs), ten-eleven translocation (TET) dioxygenases, histone acetyltransferases (HATs), and histone deacetylases (HDACs) are central to epigenetic regulation. These enzymes maintain a dynamic balance between DNA methylation/demethylation and histone acetylation/deacetylation, which critically influences gene expression and neuronal survival in IS. This review is based on both in vivo and in vitro experimental studies, exploring the roles of DNMT/TET and HAT/HDAC in IS, evaluating their potential as therapeutic targets, and discussing the use of natural compounds as modulators of these enzymes to develop novel treatment strategies.

Topik & Kata Kunci

Therapeutics. Pharmacology

Penulis (8)

Yurou Guo

Jing Li

Xiaodan Liu

Huang Ding

Wei Zhang

Format Sitasi

APA MLA BibTeX

Guo, Y., Li, J., Liu, X., Liu, X., Ding, H., Ding, H. et al. (2025). Potential therapeutic targets for ischemic stroke in pre-clinical studies: Epigenetic-modifying enzymes DNMT/TET and HAT/HDAC. https://doi.org/10.3389/fphar.2025.1571276

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Informasi Jurnal

Tahun Terbit: 2025
Sumber Database: DOAJ
DOI: 10.3389/fphar.2025.1571276
Akses: Open Access ✓