Tailored treatments in inborn errors of immunity associated with atopy (IEIs-A) with skin involvement
Abstrak
Inborn errors of immunity associated with atopy (IEIs-A) are a group of inherited monogenic disorders that occur with immune dysregulation and frequent skin involvement. Several pathways are involved in the pathogenesis of these conditions, including immune system defects, alterations of skin barrier and metabolism perturbations. Current technological improvements and the higher accessibility to genetic testing, recently allowed the identification of novel molecular pathways involved in IEIs-A, also informing on potential tailored therapeutic strategies. Compared to other systemic therapy for skin diseases, biologics have the less toxic and the best tolerated profile in the setting of immune dysregulation. Here, we review IEIs-A with skin involvement focusing on the tailored therapeutic approach according to their pathogenetic mechanism.
Topik & Kata Kunci
Penulis (20)
Carmela Giancotta
Nicole Colantoni
Lucia Pacillo
Lucia Pacillo
Veronica Santilli
Donato Amodio
Emma Concetta Manno
Nicola Cotugno
Nicola Cotugno
Gioacchino Andrea Rotulo
Gioacchino Andrea Rotulo
Beatrice Rivalta
Beatrice Rivalta
Andrea Finocchi
Andrea Finocchi
Caterina Cancrini
Caterina Cancrini
Andrea Diociaiuti
May El Hachem
Paola Zangari
Akses Cepat
- Tahun Terbit
- 2023
- Sumber Database
- DOAJ
- DOI
- 10.3389/fped.2023.1129249
- Akses
- Open Access ✓