DOAJ Open Access 2026

Development and validation of a nomogram for predicting tracheostomy risk in traumatic cervical spinal cord injury

Weiting Chen Weiting Chen Xiaoshuang Jiang Xiaoshuang Jiang Xixi Guo +6 lainnya

Abstrak

BackgroundTracheostomy is common in traumatic cervical spinal cord injury (TCSCI) because of respiratory complications, yet objective tools to estimate individual risk remain limited.MethodsIn this single-center retrospective cohort at the Second Affiliated Hospital, Zhejiang University School of Medicine, we enrolled 308 consecutive ICU admissions with TCSCI (January 2018–March 2023) and randomly split the cohort 7:3 (outcome-stratified) into training (n = 215) and validation (n = 93) sets. Candidate admission predictors were screened with Least Absolute Shrinkage and Selection Operator and then entered into multivariable logistic regression to construct a nomogram. Model performance included discrimination (AUC with bootstrap 95% CIs, 2,000 resamples), calibration (intercept, slope, Brier), and decision curve analysis (DCA). A prespecified clinical threshold of 0.30 was used to summarize sensitivity and specificity.ResultsFive independent predictors were retained—smoking history, thoracic injury, BMI ≥ 25 kg/m2, cervical dislocation, and ASIA grade (A vs. B-D). The model showed strong discrimination (AUC 0.844, 95% CI 0.788–0.896 in training; 0.903, 95% CI 0.823–0.966 in validation) and good calibration. At the 0.30 threshold, performance was Sensitivity 0.781/Specificity 0.725 (training) and Sensitivity 0.812/Specificity 0.852 (validation); DCA demonstrated greater net benefit than “treat all/none” across threshold 0.10–0.70.ConclusionA parsimonious, five-factor nomogram based on routine admission data provides accurate, clinically interpretable stratification of tracheostomy risk in TCSCI. Clear reporting of ASIA coding and a prespecified decision threshold enhance bedside usability. Prospective, multi-center external validation is warranted.

Penulis (11)

W

Weiting Chen

W

Weiting Chen

X

Xiaoshuang Jiang

X

Xiaoshuang Jiang

X

Xixi Guo

X

Xixi Guo

J

Jiuzhou Lin

J

Jiuzhou Lin

M

Min Tang

M

Min Tang

N

Nanlin Dou

Format Sitasi

Chen, W., Chen, W., Jiang, X., Jiang, X., Guo, X., Guo, X. et al. (2026). Development and validation of a nomogram for predicting tracheostomy risk in traumatic cervical spinal cord injury. https://doi.org/10.3389/fneur.2025.1684974

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Informasi Jurnal
Tahun Terbit
2026
Sumber Database
DOAJ
DOI
10.3389/fneur.2025.1684974
Akses
Open Access ✓