DOAJ Open Access 2019

Innate Immune Cells: Monocytes, Monocyte-Derived Macrophages and Microglia as Therapeutic Targets for Alzheimer’s Disease and Multiple Sclerosis

Adham Fani Maleki Serge Rivest

Abstrak

The immune system provides protection in the CNS via resident microglial cells and those that traffic into it in the course of pathological challenges. These populations of cells are key players in modulating immune functions that are involved in disease outcomes. In this review, we briefly summarize and highlight the current state of knowledge of the differential contributions of microglia and monocytes in Alzheimer’s disease and multiple sclerosis. The role of innate immunity is frequently seen as a Yin and Yang in both diseases, but this depends on the environment, pre-clinical disease models and the type of cells involved.

Topik & Kata Kunci

Neurosciences. Biological psychiatry. Neuropsychiatry

Penulis (2)

Adham Fani Maleki

Serge Rivest

Format Sitasi

APA MLA BibTeX

Maleki, A.F., Rivest, S. (2019). Innate Immune Cells: Monocytes, Monocyte-Derived Macrophages and Microglia as Therapeutic Targets for Alzheimer’s Disease and Multiple Sclerosis. https://doi.org/10.3389/fncel.2019.00355

Akses Cepat

PDF tidak tersedia langsung

Cek di sumber asli →

Lihat di Sumber doi.org/10.3389/fncel.2019.00355

Informasi Jurnal

Tahun Terbit: 2019
Sumber Database: DOAJ
DOI: 10.3389/fncel.2019.00355
Akses: Open Access ✓