Neudesin is involved in anxiety behavior: structural and neurochemical correlates
Abstrak
Neudesin (also known as neuron derived neurotrophic factor, Nenf) is a scarcely studied putative non-canonical neurotrophic factor. In order to understand its function in the brain, we performed an extensive behavioral characterization (motor, emotional and cognitive dimensions) of neudesin-null mice. The absence of neudesin leads to an anxious-like behavior as assessed in the elevated plus maze, light/dark box and novelty suppressed feeding tests, but not in the acoustic startle test. This anxious phenotype is associated with reduced dopaminergic input and impoverished dendritic arborizations in the dentate gyrus granule neurons of the ventral hippocampus. Interestingly, shorter dendrites are also observed in the bed nucleus of the stria terminalis (BNST) of neudesin-null mice. These findings lead us to suggest that neudesin is a novel relevant player in the maintenance of the anxiety circuitry.
Topik & Kata Kunci
Penulis (22)
Ashley eNovais
Ashley eNovais
Ana Catarina Ferreira
Ana Catarina Ferreira
Fernanda eMarques
Fernanda eMarques
José M Pêgo
José M Pêgo
João J Cerqueira
João J Cerqueira
Ana eDavid-Pereira
Ana eDavid-Pereira
Filipa L Campos
Filipa L Campos
Christina eDalla
Nikolaos eKokras
Nuno eSousa
Nuno eSousa
Joana A Palha
Joana A Palha
Joao C Sousa
Joao C Sousa
Akses Cepat
- Tahun Terbit
- 2013
- Sumber Database
- DOAJ
- DOI
- 10.3389/fnbeh.2013.00119
- Akses
- Open Access ✓