DOAJ Open Access 2022

The role of microglial autophagy in Parkinson’s disease

Rui Zhu Rui Zhu Yuyi Luo Yuyi Luo Shangang Li +3 lainnya

Abstrak

Parkinson’s disease (PD) is the second most common neurodegenerative disease. Studies have shown that abnormal accumulation of α-synuclein (α-Syn) in the substantia nigra is a specific pathological characteristic of PD. Abnormal accumulation of α-Syn in PD induces the activation of microglia. Microglia, which are immune cells in the central nervous system, are involved in the function and regulation of inflammation in PD by autophagy. The role of microglial autophagy in the pathophysiology of PD has become a hot-pot issue. This review outlines the pathways of microglial autophagy, and explores the key factor of microglial autophagy in the mechanism of PD and the possibility of microglial autophagy as a potential therapeutic target for PD.

Topik & Kata Kunci

Neurosciences. Biological psychiatry. Neuropsychiatry

Penulis (8)

Rui Zhu

Yuyi Luo

Shangang Li

Zhengbo Wang

Format Sitasi

APA MLA BibTeX

Zhu, R., Zhu, R., Luo, Y., Luo, Y., Li, S., Li, S. et al. (2022). The role of microglial autophagy in Parkinson’s disease. https://doi.org/10.3389/fnagi.2022.1039780

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Informasi Jurnal

Tahun Terbit: 2022
Sumber Database: DOAJ
DOI: 10.3389/fnagi.2022.1039780
Akses: Open Access ✓