DOAJ Open Access 2018

Negative Control of RpoS Synthesis by the sRNA ReaL in Pseudomonas aeruginosa

Hue Thi Bach Nguyen David Romero A. Fabian Amman Theresa Sorger-Domenigg Muralidhar Tata +2 lainnya

Abstrak

Pseudomonas aeruginosa (Pae) is an opportunistic human pathogen, able to resist host defense mechanisms and antibiotic treatment. In Pae, the master regulator of stress responses RpoS (σS) is involved in the regulation of quorum sensing and several virulence genes. Here, we report that the sRNA ReaL translationally silences rpoS mRNA, which results in a decrease of the RpoS levels. Our studies indicated that ReaL base-pairs with the Shine-Dalgarno region of rpoS mRNA. These studies are underlined by a highly similar transcription profile of a rpoS deletion mutant and a reaL over-expressing strain.

Topik & Kata Kunci

Microbiology

Penulis (7)

Hue Thi Bach Nguyen

David Romero A.

Fabian Amman

Theresa Sorger-Domenigg

Muralidhar Tata

Elisabeth Sonnleitner

Udo Bläsi

Format Sitasi

APA MLA BibTeX

Nguyen, H.T.B., A., D.R., Amman, F., Sorger-Domenigg, T., Tata, M., Sonnleitner, E. et al. (2018). Negative Control of RpoS Synthesis by the sRNA ReaL in Pseudomonas aeruginosa. https://doi.org/10.3389/fmicb.2018.02488

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Informasi Jurnal

Tahun Terbit: 2018
Sumber Database: DOAJ
DOI: 10.3389/fmicb.2018.02488
Akses: Open Access ✓