DOAJ Open Access 2026

NKG2D CAR-T cells for solid tumor immunotherapy: advances, challenges, and future directions

Chen Liu Zhiqiang Wang Wentao Zhang Guangping Cheng Siyan Cheng +6 lainnya

Abstrak

Chimeric antigen receptor (CAR) T-cell therapy has achieved significant success in hematologic malignancies, but its efficacy in solid tumors remains limited, primarily due to the immunosuppressive tumor microenvironment (TME) that hinders CAR-T cell trafficking and function. NKG2D CAR-T cells, which target stress-induced NKG2D ligands (NKG2DLs) broadly expressed on tumor cells, have shown promising potential in overcoming the immunosuppressive barriers of the solid TME. This review highlights recent advances in NKG2D CAR-T cell strategies for solid tumors, including innovations in CAR architecture, signaling pathway engineering, combination immunotherapy, and the development of armored CAR constructs. We further discuss the therapeutic potential, current challenges, and future directions of these approaches to inform the design of more effective and durable CAR-T cell therapies for solid tumors.

Topik & Kata Kunci

Immunologic diseases. Allergy

Penulis (11)

Chen Liu

Zhiqiang Wang

Wentao Zhang

Guangping Cheng

Siyan Cheng

Long Qin

Huili Ye

Wen Ren

Format Sitasi

APA MLA BibTeX

Liu, C., Wang, Z., Zhang, W., Cheng, G., Cheng, S., Qin, L. et al. (2026). NKG2D CAR-T cells for solid tumor immunotherapy: advances, challenges, and future directions. https://doi.org/10.3389/fimmu.2026.1763843

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Lihat di Sumber doi.org/10.3389/fimmu.2026.1763843

Informasi Jurnal

Tahun Terbit: 2026
Sumber Database: DOAJ
DOI: 10.3389/fimmu.2026.1763843
Akses: Open Access ✓