DOAJ Open Access 2025

Advances in immunology of obstructive sleep apnea: mechanistic insights, clinical impact, and therapeutic perspectives

Na Dong Na Dong Hongmei Yue Hongmei Yue

Abstrak

Obstructive sleep apnea (OSA) drives immune dysregulation through its hallmark stressors—intermittent hypoxia (IH) and sleep fragmentation (SF). Beyond impaired sleep, OSA acts as a systemic inflammatory trigger that disrupts immune homeostasis and reshapes both innate and adaptive responses. Recent evidence shows that OSA activates hypoxia-inducible factor-1α (HIF-1α), NF-κB signaling, and the NLRP3 inflammasome, promoting chronic inflammation and immune-cell dysfunction. These alterations mechanistically contribute to OSA-associated cardiovascular disease, metabolic disorders, cognitive impairment, and tumor progression. Reframing OSA as an immune-modulating disorder highlights the need for diagnostics and therapies guided by immunology rather than airway management alone.

Topik & Kata Kunci

Immunologic diseases. Allergy

Penulis (4)

Na Dong

Hongmei Yue

Format Sitasi

APA MLA BibTeX

Dong, N., Dong, N., Yue, H., Yue, H. (2025). Advances in immunology of obstructive sleep apnea: mechanistic insights, clinical impact, and therapeutic perspectives. https://doi.org/10.3389/fimmu.2025.1654450

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Informasi Jurnal

Tahun Terbit: 2025
Sumber Database: DOAJ
DOI: 10.3389/fimmu.2025.1654450
Akses: Open Access ✓