Case Report: Decentralized trial of tolerability-adapted exercise therapy after severe Covid-19
Abstrak
We assessed the safety, tolerability, and effects of exercise therapy in three patients with cancer and hospitalization for SARS-CoV-2 infection in an early-phase prospective trial. All study assessments and exercise sessions were conducted remotely (decentralized) in patient’s homes. Patients received five escalated doses of aerobic exercise therapy (range, 90 to 375 minutes per week) following a tolerability-based adapted schedule over 30 consecutive weeks. Exercise therapy was safe (i.e., no serious adverse events), tolerable (i.e., all exercise therapy doses were completed, with an overall average relative exercise dose intensity of 89%), and associated with improvements in patient physiology (e.g., exercise capacity) and patient-reported outcomes (e.g., quality of life). Correlative proteomic and single-cell immune sequencing of peripheral blood samples revealed marked alterations in protein and immune phenotypes implicated in post COVID-19 condition. (ClinicalTrials.gov number, NCT04824443).
Topik & Kata Kunci
Penulis (22)
Jessica M. Scott
Jessica M. Scott
Zhuyu Qiu
Zhuyu Qiu
Jahan Rahman
Chaya S. Moskowitz
Meghan G. Michalski
Sarah Lehman
Catherine P. Lee
Jenna Harrison
Anthony F. Yu
Anthony F. Yu
Amira Marouf
Amira Marouf
Santosha Vardhana
Santosha Vardhana
Paul C. Boutros
Paul C. Boutros
Paul C. Boutros
Paul C. Boutros
Lee W. Jones
Lee W. Jones
Akses Cepat
- Tahun Terbit
- 2025
- Sumber Database
- DOAJ
- DOI
- 10.3389/fimmu.2025.1529385
- Akses
- Open Access ✓